Four Wondefrul Meridians Particles ECM Remodeling In Experimental Atherosclerotic Vascular

Purpose: Four wonderful meridians particle research on experimental atherosclerosis inNew Zealand white rabbits vascular remodeling of the ECM change mechanism, observedchanges in vascular tissue morphology confirmed atherosclerotic vascular remodeling is oneof the pathogenesis, four wonderful meridians particle method in the treatment ofatherosclerotic vascular remodeling mechanisms has a therapeutic effect. Mechanism of richChinese medicine prevention of atherosclerosis and provide new treatments for clinical.Method:40New Zealand rabbits, according to body weight were randomly divided intonormal group, model group, four wonderful meridians high particle, low-dose group, westernmedicine group; modeling administered for10weeks. The expression was detected byimmunohistochemistry I, III collagen protein; through zymography staining change MMP-9activityand content; selection of protein dot blot assay thoracic aorta protein expression TIMP; throughHE staining, microscopy aortic wall plaque morphology.Result: Four wonderful meridians particles of MMP-9was significantly elevated,TIMP-1was significantly lower, MMP-9/TIMP-1ratio increased, confirming four wonderfulto balance the meridians particles of atherosclerotic vessels ECM significantly inhibited itsrole in the proliferation of accumulation. I, III collagen content decreases, I/III collagenratio increased, indicating that the particles of four wonderful meridians stable atheroscleroticvascular remodeling plaque, can reduce the extent of coronary atherosclerosis lesions.Conclusion: Four wonderful meridians particles can inhibit the development ofatherosclerosis, plaque stabilization to improve vascular remodeling. Describes the four wonderfulmeridians particles in the treatment of atherosclerotic vascular remodeling mechanism method hasa therapeutic effect, enrich the study of the mechanism of TCM prevention of atherosclerosis,provides a new clinical treatments.