Colony Distribution Infection And Drug Resistance Of Respiratory Tract In Children

Part1Distribution of children with respiratory tract infection of thecolonyObjective：Resistance is a measure of the key indicators of pathogenicbacteria has been, this paper is divided into four areas. In this part ofthe research process, mainly on lower respiratory tract infections, thedistribution of patients infected colonies were analyzed. Aimed at findingcommon clinical pathogenic bacteria colonies choose to provide thenecessary foundation for the subsequent analysis of drug-resistantcolonies.Method: In this paper, the way strains cultured sputum respiratorytract infection in children under culturing conditions, and then count thenumber of different strains, in order to characterize the distribution ofcolonies. Specific test methods: for hospital inpatient and outpatientpediatrics2012Total1000cases of respiratory specimens were cultured,and isolates were identified.Results: We found that under experimental comparison children withrespiratory tract infection, a total of1000cases of submission of samples,which isolates the sample size was437cases, accounting for43.7%of allsamples for inspection; among strains according to the number of common clinical isolates were sorted: Haemophilus influenzae (166,37.99%)>Klebsiella pneumoniae (107,24.49%)> Staphylococcus aureus (74,16%).Conclusion: According to the strain distribution, this paper considers theprocess of respiratory infections in young children, Haemophilusinfluenzae, Klebsiella pneumoniae, Staphylococcus aureus is a commonclinical bacterial infections (10%of the boundary). Has certain clinicalpathological significance in the process. It also provides the necessarybasis for the subsequent choice of strains resistant analysis.Part2Analysis of the antimicrobial resistance ofHaemophilusinfluenzae isolated from children’s respiratory tractObjective： To study the clinical feature and the antimicrobialresistance of Haemophilusinfluenzae (Hi) which were isolated from childrenrespiratory tract in the pediatrics, and to guide the rational use ofantimicrobial therapy in clinical practice.Method: A retrospective investigation was done in the50cases ofinfecting with Hi which were isolated from children respiratory tract inthe Peadiatrics in2012.Results: The drug resistance of Hi against TMP-SMZ (56.0%), ampicil(52.0%) and cafalotin (38.0%) was high. We did not discover the Hi whichwereβ-lactamase-nagative and ampicillin-resistance. While the drugs suchas rifampicin (98.0%), azithromycin (98.0%), chemicetin (96.0%),cefotaxime (96.0%), amoxicillin/clavulanic acid (94.0%), ofloxacin (92.0%)and tetracycline (90.0%) were more sensitive than other antimicrobials.Conclusion: TMP-SMZ, ampicil and cafalotin are not suitable to be usedin clinical treatment because of the high rate of drug resistance. And weshould pay more attention to the phenomenon of multidrug resistant. Azithromycin, amoxicillin/clavulanic acid and cefotaxime can be used forthe treatment of Hi infection.Part3Klebsiella pneumoniae strains resistant analysisObjective: Resistance is a measure of the key indicators of pathogenicbacteria have been, the paper resistant Klebsiella pneumoniae infectionin children with respiratory tract case were analyzed to investigate theclinical characteristics of Klebsiella pneumoniae and antimicrobial drugsresistance, clinical therapy.Methods: In this paper, the strain cultured in vitro analysis methodsfor drug resistance of Klebsiella pneumoniae, the specific experimentalmethods are: the separation of hospital inpatient and outpatient pediatricsin2012to50respiratory specimens Haemophilus influenzae retrospectiveInvestigation and Analysis.Results: We found through experiments comparing different drugsKlebsiella pneumoniae have a certain resistance, resistance to differentdrugs whose performance is different, specific results are as follows:Klebsiella pneumoniae resistance rates of50higher drug chloramphenicol(96.0%), cefotaxime (96.0%), amoxicillin/clavulanic acid (97.6%),ofloxacin (95.2%) and tetracycline (90.0%); sensitivity rate than high drugrifampin (98.0%), trimethoprim-sulfamethoxazole (71.6%), ampicillin(95.1%) and azithromycin (95.1%).Conclusion: According to the sort of drug resistance, Klebsiellapneumoniae resistant to different drugs are: amoxicillin/clavulanic acid>chloramphenicol, cefotaxime ofloxacin> tetracycline; sensitive to higherrates the drugs: cotrimoxazole> azithromycin ampicillin rifampin. Thus:cotrimoxazole, ampicillin, azithromycin and rifampin-resistant Klebsiellapneumoniae higher rate should not be used in clinical treatment, should pay attention to the phenomenon of multi-drug resistant. Clinical treatmentcan give priority to cotrimoxazole, ampicillin, azithromycin and rifampin.Evaluate the relative effectiveness of cotrimoxazole inhibition of thegrowth of Klebsiella pneumoniae best.Part4Staphylococcus aureus resistance analysisObjective: Resistance is a measure of the key indicators of pathogenicbacteria has been the paper Bauman children with respiratory tractinfection in case resistance of Acinetobacter were analyzed to investigatethe clinical characteristics of Staphylococcus aureus and antibacterialdrugs resistance, clinical therapy.Methods: In this paper, the way of culture strains of Staphylococcusaureus resistance in vitro analysis of specific experimental methods: forhospital inpatient and outpatient pediatrics2012respiratory specimensisolated from50Staphylococcus aureus be retrospective analysis.Results: We found that experimental comparison of Staphylococcusaureus different drugs have a certain resistance, resistance to differentdrugs whose performance is different, specific results are as follows:50Staphylococcus aureus resistance rates higher drug amoxicillin/clavulanic acid (37.5%), cefotaxime (25.2%), ofloxacin (25.2%),trimethoprim-sulfamethoxazole (42.3%), and ampicillin (31.6%); sensitivehigher rate of drug rifampicin (80.3%), chloramphenicol (93.7%),tetracycline (93.7%) and azithromycin (92.9%).Conclusion: According to the sort of drug resistance, Staphylococcusaureus resistant to different drugs were: cotrimoxazole> amoxicillin/clavulanic acid> ampicillin> cefotaxime ofloxacin; sensitive rate Higherdrugs: tetracycline chloramphenicol Azithromycin> rifampin. Thus:cotrimoxazole, ampicillin, and amoxicillin/clavulanic acid-resistantStaphylococcus aureus higher rate should not be used in clinical treatment, should pay attention to the phenomenon of multi-drug resistant. Clinicaltreatment can give priority to chloramphenicol, azithromycin and rifampin.Evaluate the relative effectiveness of inhibition, chloramphenicol growthof Staphylococcus aureus best.