The Assessment Of Early Prognosis After Liver Transplantation By Transient Elastography

Purpose:To investigate the clinic value of transient elastography in adult after liver transplantation, by means of evaluating the correlation of liver stiffness measured by FibroScan with liver/renal functions.MethodForty-three patients received orthotopic liver transplant in our hospital during2013.12.10and2014.3.19were included in this study. Liver stiffness measurement was performed after transplantation.Clinical data and laboratory tests including liver function and renal function were collected and analyzed.Result①Bivariate correlation showed that body mass index(BMI), MELD score,graft-to-recipient weight ratio(GRWR) and warm ischemia time had no correlation with liver stiffness measurement(LSM). LSM of the1st day after transplantation(LSM-1 showed no correlation with cold ischemia time,but LSM of the7th day after transplantation(LSM-7) did, with R=0.335and P=0.028. LSM-1showed positive correlation with the ICU time (R=0.488,P=0.001), but LSM-7didn’t. There were significant positive correlation between LSM and aspartate aminotransferase,bile acid and creatinine; no significant correlations were found between LSM and alanine aminotransferase,alkaline phosphatase,cholinesterase,gamma-glutamyl transferase,total bilirubin,direct bilirubin,indirect bilirubin,urea nitrogen and uric acid.②The group with higher LSM-1had longer ICU time than the lower group(9d vs7d, P=0.013), and so was the hospital time(34d vs23d,P=0.023). For the LSM-7, there were no significant difference in ICU time nor hospital time between the two groups. The group with higher LSM-1had higher serious complication incidence than the lower group(78.57%vs27.59%, P=0.002),but the two groups in LSM-7showed no significant difference in serious complication incidence.ConclusionThe LSM partially correlates with the liver function and renal function of liver transplantation recipient, and may has its value for the assessing of early prognosis.