Analysis Of Related Clinical Factors And Prognosis Of Microvascular Invasion In Hepatocellular Carcinoma

Objective:(1)Through the large sample analysis to explore the correlation of microvascular invasion in hepatocellular carcinoma and gender, age, history of hepatitis, liver function, Child stage, AFP level, large vessel invasion,tumor size and number, pathological pattern, Clinical staging and grading.(2)To assess the prognostic significance of microvascular invasion in hepatocellular carcinoma patients.Materials and methodsIn this study,136cases of liver cancer were obtained from the second affiliated hospital of zhe jiang university between2007and2014. The clinical,pathological and image data were reviewed respectively.Use SPSS17.0for statistical analysis.According to pathological results,cases were divided into microvascular invasion group and non-microvascular invasion group.Age,liver function,AFP level,tumor size and number were compared by T-test or Wilcoxon rank test. Gender,history of hepatitis, Child stage,large vessel invasion,pathological pattern,clinical staging and grading were compared usingχ2test. Correlation between microvascular invasion and these clinical factors were analyzed by Logistic regression model.(2)The above clinical factors were compared for their possible association with patient’ survival, using the kaplan-meier and Log-rank test in the univariate analysis and the COX proportional hazard regression model in the multivariate analysis.Results:No statistically difference were found between the two groups in gender, liver cirrhosis, age, liver function,tumor number. Difference of AFP level, tumor size, large vessel invasion, Child stage, clinical staging and grading were statistically significant. Regression coefficient between microvascular invasion and treatment tumor size, tumor number, large vessel invasion, clinical staging, clinical grading were statistically significant. Univariate analysis showed that, for the treatment, tumor size and number, macrovascular invasionliver function, liver cirrhosis, metastasis, microvascular invasion. Multivariate analysis demonstrated that treatment, tumor size, tumor number, macrovascular invasion, liver function and microvascular invasion were independent predictors of survival.Conclusion:Microvascular invasion correlated with AFP level, tumor size, large vessel invasion, Child stage, clinical staging and grading statistically and was independent predictor of prognosis.