| Background and Ojectives:Progressive ischemic stroke (PIS), which is also called progressive stroke orstroke in progression (SIP), refers to the acute ischemic stroke with mild neurologicaldeficits as first manifestation, but with a continuous or stepwise increase in neurologicalsymptoms6hours after the onset. The morbidity and mortality of patients of SIP weresignificantly higher than those of non-progressive stroke patients. Therefore, in orderto improve the prognosis of SIP, we need to intervene in the related risk factors.Dyslipidemia is a major risk factor for cardiovascular diseases. The research aims atexploring the relationship between the development of SIP and related risk factorsincluding the serum levels of TC, TG,LDL-C, HDL-C and Lpa.Methods:Using the program Epidata3.1to establish a database, collecting the followingclinical data of194patients-blood pressure, serum total cholesterol, triglycerides,high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, lipoproteinsand fibrinogen test results. Analyze the data by the program SPSS17.0. First, todetermine whether datasets follow a normal distribution. We use X±S to representthe central tendency and dispersion trend of those datasets that follow a normaldistribution, and apply t test to test the difference of the means of two independentpopulations with unknown variances; for the abnormal distribution of measurementdata, we use M±Q to represent their central tendency and dispersion trend, and carryout the Kruskal-Wallis test to test the difference; we use rate or constituent ratio torepresent the enumeration data, and apply χ2test to determine the difference between the two groups.Results:1.(1) The incidence of SIP is higher when the range of TC is between3.84mmol/L to4.66mmol/L than when the TC is lower than3.84mmol/L (71.0%vs33.3%). The incidence of SIP is higher when the range of TC is between3.84mmol/Lto4.66mmol/L than when the TC is higher than4.66mmol/L (71.0%vs53.7%)(2)The incidence of SIP (33.3%) is lower than that (66.7%) of non-progressive strokewhen TC is lower than3.84mmol/L. However when when TC is between3.84mmol/L to4.66mmol/L, the incidence of SIP (71.0%) is higher than that (29.0%) ofnon-progressive stroke.2. The incidence of SIP is higher when the range of TG is between0.85mmol/Lto1.16mmol/L than when TG is lower than0.85mmol/L (71.1%vs33.3%).3.The incidence of SIP is higher when the LDL-C level is higher than4.39mmol/L than when LDL-C is in a range between2.90mmol/L to4.39mmol/(83.3%vs50.5%). And when LDL-C level is higher than4.39mmol/L, the incidenceof SIP is higher than when LDL-C level is lower than2.90mmol/L (83.3%vs58.2%).4.The incidence of SIP is higher when the HDL-C level is lower than1.16mmol/L than when the HDL-C is in the range of1.16mmol/L to1.28mmol/L(60.4%vs36.4%).5.(1) When LPA is in a range between0.13mmol/L to0.37mmol/L, theincidence of SIP is higher than when LPA is lower than0.13mmol/L (68.9%vs39.3%).(2) When the LPA level in serum is lower than0.13mmol/L, the incidence ofSIP is lower than that of non-progressive stroke (39.3%vs60.7%). But when the LPAlevel in serum is ranging from0.13mmol/to0.37mmol/L, the incidence of SIP ishigher than that of non-progressive stroke (68.9%vs31.1%). Conclusions:(1) When serum TC and LPA are in a low level, the incidence of SIP is lowerthan that of non-progressive stroke; when those are in a medium level, the incidenceof SIP is higher than that of non-progressive stroke. Hence, keeping TC under thelevel of3.84mmol/L and LPA under0.13mmol/L is good for preventing thedevelopment of SIP.(2) In general, this study revealed no significant difference between the incidenceof SIP and non-progressive stroke when comparing serum cholesterol, triglycerides,high density lipoprotein, low-density lipoproteins between these two groups.(3) When TC is in a medium level, the incidence of SIP reaches its peak; theincidence of SIP is highest when LDL-C in serum is in a high level. The incidence ofSIP is lower When TG and LPA in serum are in a low level than in a medium level.The same incidence is higher when HDL-C in serum is in a low level than when it’s ina medium level.(4) We have preliminarily come up with a SIP occurrence access scale based onthe blood lipid level, which could help us access the occurrence rate of SIP in theclinic. |
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