A Retrospective Analysis Of Sentinel Lymph Node Biopsy In879Cases Of Early Breast Cancer

Objective: sentinel lymph node biopsy confirmed by many international largescaleclinical randomized controlled trial has become clinical axillary lymph nodes in breast cancerpatients with negative axillary surgery standard surgical treatment. The aim ofThis study is toexplore the factors that affect the success rate and metastasis of sentinel nodes.Materials and methods: This is a retrospective analysis of the clinical and pathologicaldata of January2007December2014Jilin University first hospital treated breast surgery in879patients underwent sentinel lymph node biopsy in patients with early stage breast cancer.All cases, preoperative axillary lymph node clinical evaluation were negative. To calculate thesuccess rate of sentinel lymph node biopsy, analyze the different pathological results ofsentinel lymph nodes, and compare the effect of different clinical pathological parameters tosentinel lymph node metastasis. Using the SPSS17.0statistical software for data processing,the difference between the two groups were compared using chi square test, necessary whenusing Fisher’s exact test, P <0.05was statistically significant.Results: the blue dye combined with radionuclide method was the most, accounting for71.1%(625/879), followed by blue dye method and blue dye combined fluorescence method.The successful rate of the sentinel lymph nodes was5in99.4%cases. The blue dye methodalone success rate was98.8%168/170and blue dye in combination with radioactive nuclidemethod success rate was99.5%(622/625) and blue dye and fluorescence method success ratewas100%(84/84)(P>0.05). The false negative rate of SLN was10.4%(), and the falsenegative rate was17(17/164). SLN detected1-25, with an average of3.5and a median of4.Results:751cases were negative in SLN,123cases were positive,718cases were negative,18cases were ITC,23case was slight metastasis, and115case was macro metastasis.Located in the area of the lesions of nipple areola SLN metastasis rate is highest,35%(p<0.001). With the increase of T staging, the SLN transfer rate increased (p<0.001). TheSLN metastasis rate of the tumor thrombus in the vasculature was68.6%, higher than that ofthe cases without tumor thrombus (p<0.001). The SLN transfer rate of ER positive cases was 4.9%, higher than that of the negative ones (p<0.001),16.3%. The SLN transfer rate of ALuminal and B was higher than that of three shade and HER-2type (p=0.015).Conclusion: the factors that affect the SLN metastasis include the location of primarytumor, T staging, pathological type, estrogen receptor, vascular invasion and moleculartyping.Conclusion: the factors that affect the SLN metastasis include the location of primarytumor, T staging, pathological type, estrogen receptor, vascular invasion and moleculartyping.