Objective: To observe the effect of gender on prognosis in patients recieving implantation of Biodegradable Polymer-coated Sirolimus-eluting Stent(BP-SES), as well as the distribution of the novel risk factors in those patients.Methods:A total of 1829 patients, consisting of 1243(68.0%)men and 586(32.0%) women, were extract from prospective I-LOVE-IT 2 study at 32 centers in China and were exclusively treated with Biodegradable Polymer-coated Sirolimus-eluting Stent(BP-SES) and Durable Polymer Sirolimus-eluting Stent(DP-SES, Tivoli®). Clinical features, coronary angiographic results, PCI outcomes and the 12-month incidence of target lesion failure(TLF), a composite endpoint including cardiac death(CD), target vessel myocardial infarction(TVMI) and clinical indicate target lesion revascularization(i-TLR), were collected and analyzed according to gender difference.Results: Diabetes mellitus(DM), hypertension and cardiac failure were more common in female patients, the mean reference vessel diameter of whom were also much smaller. There were more smokers and patients who ever suffered from myocardial infarction(MI) or reecived PCI in the group of man. There was no significant difference on the incidence of TLF between male and female patients(7.90% vs 5.58%, P=0.06).However, the incidence of TVMI was markedly higher in the group of woman(5.33% vs 2.83%;P<0.01). Besides, 6-month clopidogrel therapy showed no increase on the incidence of TLF compared with the prolonged 12-month strategy.Conclusion: Gender had no effect on the incidence of total rate of TLF, but significantly affecting the rate of TVMI in CHD patients receiving impaltation of BP-SES. Moreover, Six-month DAPT therapy is euqally safety compared with polonged Twelve-month strategy in patients implanted with BP-SES. |