The Clinical Analysis Of 186 Cases Of Lung Ground-glass Nodules

Objective : Retrospectively analysis the clinical data of solitary pulmonary Ground-Glass Nodules, which includes general information, imaging findings,laboratory test results, the histopathological examination, diagnosis and treatment situation. Summarizes the characteristics of the clinical data, in order to improve the understanding of Ground-Glass Nodules, provide reference for clinical diagnosis and treatment.Methods:I conducted a retrospective study of the clinical data of 186 patients with GGN who underwent surgery treatment in the First Affiliated Hospital of Dalian Medical University from January 2014 to December 2014. A detailed record of the general information, imaging manifestations and characteristics, molecular biology index operation way, postoperative pathological characteristics, the normal reference values for standard laboratory department of hospital. Using Microsoft Excel to establish a database, and statistical analysis was performed using SPSS17.0 software.Results:According to the pathological types, 186 cases of solitary ground-glass nodule patients are divided into invasive group and non invasive group.Histopathological manifestations of invasive in 127 cases, including micro infiltrating adenocarcinoma(MIA, n = 58), invasive adenocarcinoma(IA, n=66), invasivemucinous adenocarcinoma(n = 3), lymph node metastasis were not dected in this group;Non infiltrating adenocarcinoma in 59 cases, including adenocarcinoma in situ(AIS, n= 42), and atypical adenomatous hyperplasia(AAH, n = 14), benign lesions(including 2cases of inflammation, 1 case of focal fibrosis). In 186 patients the ratio of male to female was 1:2.44, the average age was 59.47 y. The minimum age is 30 years old, the maximum is 79 y. From 50 to 70 y of age accounted for 70.59% of all patients. For general clinical data(age, sex, smoking history, hypertension, diabetes), serum tumor marker cytokeratin 19 fragment(CYFRA21-1) and carcinoembryonic antigen(NSE),there was no statistically significant difference in two groups(P > 0.05). Lesion size, lesion shape(round/ quasi-circular, irregular shape), leaf margin, alobulated internal structure of the existing air bronchogram, adjacent structures(pleural retraction,vessels cluster) in the two groups was statistically significant difference(P < 0.05). As for the spicule sign and the vacuole sign,there are no statistically significant difference in the two groups(P > 0.05).Conclusion:1.The solitary pulmonary ground glass nodules occurred in 50 ~ 70 y,and its invasiveness has no obvious correlation with age, sex, smoking history and lesion location. 2. There are not correlation between the extent of tumor invasion and the serum tumor markers(CYFRA21-1 、 CEA). 3. Ground glass nodule which has manifestations of large diameter, solid component, irregular in shape, lobulation, pleural indentation sign and vascular convergence on HRCT prefer invasive.