Studies On The Chemical Constituents And Bioactivities Of Two Medical Plants

The thesis consists of four chapters. Chapter one presented a review on the chemical constituents and bioactivities of plants of the genus Rhododendron. The second chapter discussed the chemical constituents and bioactivities studies on the roots and stems of Rhododendron microphyton. Chapter three dealed with the isolation and determination of the chemical constituents of Tripterygium regelii. And the last chapter concluded the whole thesis.In Chinese traditional medicine, Rhododendron microphyton has been widely used for centuries in the treatment of cold, convulsion, nephritides by people of the minority areas of Yunnan province. As a continuation of our search for more new natural compounds with biological activities, twenty two compounds were isolated from the roots and stems of R. microphyton, including four new iridoids and one new monoterpenoid:incarvoid D (1), incarvoid E (2), incarvoid F (3), incarvoid B-9-O-β-D-glucopyranoside (4), argutoid B (5). This is the first report of R. microphyton.Tripterygium regelii, well known traditional medicinal plant, has been used instead of Tripterygium wilfordii for the treatment of diseases due to its lower toxicity, such as chronic infectious arthritis, swelling pain, bruises and itching. In addition, T. regelii had been used as an important ingredient of the plant medicine in the treatment of snakebite. Our further investigation of this plant collected from Changbai Mountain of Northeastern China led to the isolation of 32 known compouds.