Clinical Study On Diarrhea Type Of Irritable Bowel Syndrome Treating By Tong Xie Yao Fang And Xiang Lian Wan

Objective:Through the clinical study of Tong Xie Yao Fang and Xiang Lian Wan in treating diarrhea type of irritable bowel syndrome,to evaluate its clinical efficacy for the treatment of TCM liver stagnation and spleen deficiency of diarrhea-predominant irritable bowel syndrome,and in theory,clinical research and research-related experiments to explore its mechanism of action for the future to further promote the use of preparatory work to do.Methods:From diarrhea cases in the Hubei Province hospital of Traditional Chinese Medicine,affiliated Hospital of Hubei University of Chinese Medicine,of Digestive Diseases from April 2013 to October 2014 during the outpatient clinic,choose a fulfilling IBS Rome Ⅲ diagnostic criteria,80 patients with TCM typing syndrome of liver stagnation and spleen deficiency,based on the patient has treatment order and informed consent,patients were randomly divided into treatment group and control groups.Two groups of patients were no significant differences in average age,sex,duration of treatment before clinical symptoms and total score,comparable(P>0.05).The treatment group is total 40 cases,including 13 males and 27 females,be Tong Xie Yao Fang and Xiang Lian Wan treatment,consisting of the main square Baizhu15g,Chishao 20 g,Baishao 20 g,Fangfeng 10 g, Chenpi 10 g,Muxiang 10 g,Huanglian 6g,Wuzhuyu 3g,Huoxiang 10 g,Peilan 10 g,Machixian 15 g, Baijiangcao 15 g,Hezi 10 g,Qianshi 10 g, Shiliupi 10 g,Wubeizi 10 g,Fuling 15 g,Yiyiren 30 g.These drugs a Day one,twice,half an hour before breakfast and dinner,each 100 ml.Control group is total 40 patients,including 16 males and 24 females,be pinaverium bromide tablets every 50 mg,three times a day,orally.In a month for a course of treatment.Safety before and after treatment were observed(including general medical projects,blood,urine,feces three conventional project examination,liver and kidney function,ECG,electronic colonoscopy and adverse reactions may occur) and the effect of observation(contain signs and symptoms, such as) to all the cases.During treatment referral group medication once a week,according to the symptoms Differentiation Modified adjust medication,in addition to the control group was not outside Shute other medications.Full month after treatment,each patient records related conditions,compared to the treatment group and the control group were observed two groups of patients before and after taking the main clinical symptoms improve recovery,etc.,the total effect of clinical symptom scores between the two groups of patients before and after the change in medication,the data to be statistical analysis.Statistical analysis:Data application SPSSl9.0 statistical software for analysis.Count data using x2 test,measurement data using the t test.Results:1.In treatment group,8 cases were cured,17 cases were markedly effectived, 11 cases were effectived,4 cases were ineffectived,the total efficiency is 90.0%.In the control group, 5 cases were cured,14 cases were markedly effectived,10 cases were effectived,11 cases were ineffectived,the total efficiency is 72.5%.The total efficiency of the treatment group is better than the control group(P<0.05).2.Two groups of patients before and after treatment symptom total score were significant differences(P<0.05).3.Treatment group improved stool frequency,abdominal distension,bowel vector gas, two threatened fullness,emotional anxiety,depression or irritability and other than the control group(P<0.05) on the symptoms,the difference was statistically significant;two in improving bowel movements shape abnormalities, loss of appetite,malaise,fatigue,tired considerable effect on symptoms(P>0.05),the difference was not statistically significant.4.In the clinical observation process, the two groups were not found significant adverse reactions.Conclusion:Using the Tong Xie Yao Fang and Xiang Lian Wan treatment of diarrhea-predominant irritable bowel syndrome,liver stagnation and spleen deficiency TCM syndrome patients,the treatment can significantly main clinical symptoms and improve patients’ mental,psychological state,comprehensive treatment,a significant improvement in terms of symptoms and signs,to determine its clinical efficacy,compared with Western medicine alone has some advantages,and has good prospects for clinical application,it is worth in clinical widely used.