The Clinical Research Of Low-Frequency Electrical Acupoint Stimulation On Post-Stroke Patients With Insomnia And The Concentration Of Plasma 5-HT, DA

Background Insomnia,Ancient literature called "Insomnia", "no sleep", "not lying", refers to the long period of sleep can not meet the normal needs of a class-based disease common disease,stroke patients is common and a certification of.Think like a general, about 20%-40% of stroke patients is associated with insomnia.However, according to other reports show the incidence of insomnia after stroke is much higher than this.Palomaki et al observed that up to 68% when accompanied by insomnia stroke patients admitted to hospital, the data is much higher than the general population.Insomnia may be extended rehabilitation of stroke patients, to further reduce the quality of life of patients, because insomnia could further damage the patient’s language, cognitive, self-care ability and other neurological and motor function.Therefore, the treatment of insomnia solved after stroke.Modern research has found that sleep is the central nervous system and the brain neurotransmittersparticipate completed.Neurotransmitters in the brain after a stroke change occurs,so causing insomnia.For the current study,insomnia and post-stroke less neurotransmitters,From that point on this subject, Research on the use of low-frequency electrical acupoint stimulation on post-stroke patients with insomnia and on the concentrations of plasma 5-HT、DA.Thus developed a new way to treat insomnia.Objective This topic randomized controlled method to combine the low-frequency electrical acupoint stimulation and drug treatment without any treatment group and control group as a reference,Was designed to investigate the low-frequency electrical acupoint stimulation after stroke plasma 5-HT,DA concentrations in patients with insomnia clinical mechanism,For the clinical treatment of stroke insomnia open up a new Method.Methods90 Cases of this issue were selected from Wuhan city hospital outpatient and inpatient rehabilitation patients.Collection time from February 2013 to February2014,Press confirmed the order randomly divided into low-frequency electro-acupuncture treatment group of 30 patients, 30 cases of drug treatment group, the control group of 30 patients.①Acupuncture treatment group(Low frequency pulse electric acupoint stimulation group): Selection of Japanese production HL-3 type warm low-frequency pulse therapeutic apparatus,Rated voltage 220V(50-60Hz),Maximum output current 19.5m A.When treating let a patient lying in bed treatment,The one positive electrode(area 9.0cm×7.0cm)close to the patient Dazhui,Two negative electrode(area8.0cm × 6.0cm) close to the patients with bilateral Shenshu.Trapezoidal, between 3-14 Hz output frequency,stimulus intensity degree of patient tolerance, treatment time 20 min, 1 times / d, 15 d for a course of treatment, were treated two courses.② Drug treatment groups:Estazolam tablets administered to patients orally, every 1mg, 1 times / night, 15 days of continuous treatment for a course of treatment, a total of two courses of treatment.③ In the control group:Not any treatment for the patient to eliminate doubt, given only a placebo, the same way as drug treatment group.After two courses, three unified set of data for analysis. Statistical before treatment, after two courses of treatment and patient PSQI index and plasma5-HT, DA concentration two months later, and statistical clinical efficacy.Results① Three groups of patients before and after treatment, two courses, two months after the PSQI index, within the group were significantly different(P <0.05), indicating that treatment had some effect.① After two courses, three groups of patients PSQI index:combined treatment group and the control group there was a significant difference(P <0.05), combined treatment group and the medical therapy group was significantly different(P <0.05), the drug treatment group and the blank the control group had a significant difference(P <0.05).③ After two courses, three groups of patients 5-HT, DA concentrations have been changed, the combination therapy group compared with the drug treatment group, there was a significant difference(P <0.05), combined treatment group and the control group there was a significant difference(P <0.05), there are differences(P <0.05) combined treatment group and treatment group.Conclusion Low-frequency electrical acupoint stimulation of 5-HT, DA plasma concentrations in patients with post-stroke positive impact insomnia, insomnia has a significant therapeutic effect, worthy of promotion.