| AIM:To investigate the value of magnetic resonance elastography (MRE) with regard to assessing liver functional reserve by measure the stiffness of non-tumor liver and then explore the relationship with liver function reserve test.METHODS:Data from inpatients diagnosed with hepatocellular carcinoma (HCC) at an interventional radiology department from July2013to December2014were analyzed. A3.0Tesla magnetic resonance unit was used to scan39patients with confirmed diagnoses of HCC; an MRE sequence was added to the protocol and the data were reconstructed. Regions of interest (ROIs) were identified in different slices of the non-tumor liver parenchyma to measure average stiffness. In addition, the indocyanine green (ICG) test was performed no more than1week before or after the magnetic resonance examination for all39patients; the ICG retention rate at15minutes (ICGR-15) and the ICG plasma clearance rate (ICG-K) were recorded. Correlational analyses were performed between the liver stiffness values and the ICGR-15as well as between the LS values and the ICG-K.RESULTS:Magnetic resonance imaging, including an MRE sequence and the ICG test, was performed successfully in all39enrolled patients. The average liver stiffness value of the non-tumor parenchyma measured using MRE in HCC patients was4.9±2.2kPa. The average ICGR-15was (10.05±8.10)%, and the average ICG-K was0.18±0.07. We found that the liver stiffness value of the non-tumor parenchyma was significantly and positively related to the ICGR-15(r=0.738P<0.01) as well as significantly and negatively related to the ICG-K (r=-0.604P±0.01). The ICGR-15was significantly and negatively related to the ICG-K (r=-0.788P<0.01). The liver stiffness of non-tumor parenchyma in normal liver functional reserve patients and abnormal patients was3.8±1.2VS6.8±2.2Kpa(P<0.0001).CONCLUSION:MRE is accurate and non-invasive; furthermore, it can be used to effectively assess the liver functional reserve of HCC patients. |
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