Analysis Of Clinical Prognosis Factors For Endoscopic Submucosal Dissection In Gastrointestinal Neuroendocrine Neoplasm

Aims:The aim of this study is to evaluate the feasibility of endoscopic submucosal dissection(ESD) for Gastrointestinal Neuroendocrine Neoplasm(NEN) and epithelial neoplasia(EN) analyze the risk factors of complications of NEN.Methods:Our research retrospect21patients who under ESD procedure in The2nd Affiliated Hospital of Zhejiang University, school of medicine from January in2007to December in2014.Those patients all had gastrointestinal neuroendocrine neoplasm diagnosed by pathology. Meanwhile,40patients are chosen from all patients who diagnosed as gastrointestinal epithelial neoplasia and treated by ESD. Factors including sex, age, lesion location, type, size, bleeding volume, complications were analyzed. The risk assessment for tumor was taken according to the microscopic characters of the tumors.Result:The analysis showed that there were significant differences of factor of size, bleeding volume and complications, while not of factors such as sex, age and type between two groups.(p<0.05).The logistic regression analysis showed that only size was an independent risk factors of complications of ESD for NEN. In those7cases with complications,2patients suffered delayed bleeding,5cases received surgery after endoscopic resection for suspected positive margin or lymphatic-vascular involvement.Conclusion:ESD is feasible and effective for Gastrointestinal NEN, but the bleeding volume and the rate of complications will be much greater than ESD for gastrointestinal epithelial neoplasia. Lesioin size is the independent risk factor which may serve as indicator of an unsuccessful ESD procedure..