Diagnosis And Correlation Between Dynamic Contrast Enhanced MR And Diffusion Weighted Imaging Of Cervical Cancer By 3.0T

Objective: To investigate whether quantitative parameters of volume transfer constant(Ktrans)can quantitatively differentiate normal cervix of uterus and cervieal cancer by dynamic contrast enhanced MR(DCE-MRI)of 3.0T, and exploring the correlation between quantitative parameters of dynamic contrast enhanced MR(DCE-MRI) with apparent diffusion coefficient(ADC).Materials and Methods: Routine MRI,dynamic contrast enhance MRI(DCE-MRI) and diffusion weight imaging(DWI) were performed successively in 26 patients with pathologically proved cervical cancer. DWI was performed with b values of 0,800s/mm2 。Mean Ktrans values of normal cervix of uterus and cervical cancer were analyzed by One-Sample T Test. Additionally, correlations between quantitative parameter and ADC value of the cervical carcinoma were evaluated by Pearson product moment coefficient.Results:1.The Ktrans values of normal cervix of uterus tissues were(0.573±0.230)/min, while those values of cervical cancer were(1.597±0.480)/min. The differences of Ktrans values between normal cervix of uterus tissues and cervical cancer were statistically significant(t=5.331,P<0.05).2. The Ktrans values of cervical cancer were(1.597±0.480)/min. And the mean ADC values of cervical cancer were(1.069±0.533)×10-3 mm2/s, there were significant positive correlations between Ktrans and ADC(r=0.440,P=0.024).Conclusion:1. Quantitative parameters of DCE-MRI can be used to quantitatively discriminate cervical cancer from normal cervix of uterus, which is potentially helpful for the diagnosis and therapy of cervical carcinoma.2.There were significant positive correlations between Ktrans and ADC of cervical cancer. There is a certain degree of positive correlation between them.