Clinical Significance Of D-dimer, PT、 FIB And PLT In Patients With Ulcerative Colitis

Objective: To analyze the clinical significance of D-dimer, PT, FIB and PLT measurement, to observe whether or not there is a hypercoagulable state or secondary hyperfibrinolysis in patients with active ulcerative colitis, and to assess whether or not D-dimer, PT, FIB, and PLT can be used as markers to evaluate the severity of the disease.Methods: To analyze retrospectively 56 UC patients hospitalized from May 1, 2014 to February 1, 2015 in the First Affiliated Hospital of Dalian Medical University. General data, coagulation index and routine hematology index were collected in this study. SPSS19.0 software was used for the statistical analysis, p<0.05 was considered to be of statistical significance.Results:1. General data: among the 56 UC patients, 32 patients were male and 24 female, the ratio of male and female was 1.33:1. The patients’ age was ranged between 16 to 75 years with an average age being 43.91±15.27 years.2. Chronic recurrent type was observed in 42 cases(75%) and initial type was observed in 14 cases(25%); proctitis type(E1) in 11 cases(19.64%), left colitis type(E2) in 29 cases(51.79%), extensive colitis type(E3) in 16 cases(28.57%); there were 22 mild cases,(39.29%), 25 moderate cases(44.64%) and 9 severe cases(16.07%).3. The relationship between the severity of the disease and blood coagulation tests:3.1 The severity of the disease and D-dimer: there is a statistical significance in UC patients with D-dimer in different conditions(F=5.12,p=0.010<0.05; there is a positive correlation between D-dimer and the severity of the disease(r=0.44>0, p=0.002<0.05).3.2 The severity of the disease and PT: there is a statistical significance in UC patients with PT in different conditions(F=6.89,p=0.002<0.05); there is a positive correlation between PT and the severity of the disease(r=0.38>0, p=0.004<0.05).3.3 The severity of the disease and APTT: there is a statistical significance in UC patients with APTT in different conditions(F=3.20, p=0.049<0.05); there is no correlation between APTT and the severity of the disease(r=0.12, p=0.387>0.05).3.4 The severity of the disease and FIB: there is a statistical significance in UC patients with FIB in different conditions(F=14.73, p=0.000<0.05); there is a positive correlation between FIB and the severity of the disease(r=0.65>0, p=0.000<0.05).3.5 The severity of the disease and PLT: there is no statistical significance in UC patients with PLT in different conditions(F=0.35, p=0.709>0.05); there is a positive correlation between PLT and the severity of the disease(r=0.29,p=0.030<0.05).4. Treatment and evaluation of curative effect:4.1 General data: 17 patients receiving infliximab therapy, 10 cases were male and 7 female, the average age being 40.71±15.19 years. The outcome: relieved in 7 cases, effective in 8 cases, ineffective in 2 cases. Remission rate was 41.18%, effective rate was 88.24%.4.2 The comparison of laboratory tests before and after infliximab therapy:4.2.1 The comparison of routine laboratory tests before and after infliximab therapy: there is a statistical significance of Hb in UC patients before and after treatment(t=3.52,p=0.003<0.05); there is a statistical significance of ALB in UC patients before and after treatment(t=4.60,p=0.000<0.05); there is a statistical significance of ESR in UC patients before and after treatment(t=5.10, p=0.000<0.05); there is a statistical significance of CRP in UC patients before and after treatment(t=2.90,p=0.012<0.05).4.2.2 The comparison of blood coagulation tests before and after infliximab therapy: there is a statistical significance of D-dimer in UC patients before and after treatment(t=2.64,p=0.018<0.05); there is a statistical significance of PT in UC patients before and after treatment(t=5.02,p=0.000<0.05); there is a statistical significance of APTT in UC patients before and after treatment(t=4.68,p=0.000<0.05); there is a statistical significance of FIB in UC patients before and after treatment(t=5.84,p=0.000<0.05); there is a statistical significance of PLT in UC patients before and after treatment(t=6.03,p=0.000<0.05).Conclusion:1. D- dimer, PT, FIB can be used to evaluate the severity of UC, there is a positive correlation between D-dimer, PT, FIB and the severity of the disease.2. Infliximab is effective in inducing remission in patients with UC in a short term.3. D-dimer, PT, APTT, FIB, and PLT can be used to evaluate the effect of treatment in UC.