The Study On The Relationship Between Obstructive Sleep Apnea Hypopnea Syndrom Insulinwith C Peptide, Leptin And Testosterone

Objective:The study mainly discusses the correlation Obstructive between, Sleep Apnea Hypopnea syndrom (Obstructive Sleep Apnea Hypopnea Syndrome, OSAHS) patients sleep monitoring index and body measurements, and serumlevels testosterone of insulin, C-peptide and the leptin, and also explores the correlation of OSAHS patients severity and the serum hormone levels.methods:Through stratified random sampling from five universities in Kunming southeast northwest as the research target, the author collects3085 questionnairesfrom the stuffat school. Through the questionnaires,322 people with filter OSAHS highrisks are selected from January 2013 to September 2013, including snoring sleep during, daytime sleepiness, ESS scale (Epworth sleeponess scale, ESS) scores more than 9 points, and at high risk for nighttime polysomnography a continuous 7 hours or more. There are 104 people diagnosed with OSAHS. On the second day morning, random draw the blood of 49 patients with OSAHS, With enzyme-linked immunosorbent (enzyme-linked immunosorbent assay ELISA) method to determine theserum levels of testosterone, insulin, C-peptide and leptin.Conclusion:①.There is a significancepositively correlate on between Apnea Hypopnea Index and body mass index (bmi), waist hip ratio, weight, (p<0.05).②. There is a significancenegatively correlate on between lowest oxygen saturationduring sleep and body mass index (bmi), waist hip ratio, weight, (p<0.05).③. There is a significancepositively correlate on between longest apnea time and body mass index, weight, (p<0.05).④.There is a significance negatively correlate on between of OSAHS patients serum testosterone levels and sleep monitoring of AHI, longest apnea time;There is a significance positively correlate on between of OSAHS patients serum testosterone levels and sleep monitoring of lowest oxygen saturation, but smaller correlation (p>0.05) has no statistical significance.There is a significance negatively correlate on between serum levels testosterone and age, waist-hip ratio, (p<0.05).⑤. There is a significance positively correlate on between of OSAHS patients serum insulin c-peptide levels and AHI、longest apnea duration, (p< 0.05);There is a significance negatively correlate on between of OSAHS patients serum insulin、c-peptide levels and lowest oxygen saturation, (p<0.05).⑥. There is a significance positively correlate on between of OSAHS patients serum leptin levels and AHI, There is a significance negatively correlate on between of OSAHS patients serum leptin levels and lowest oxygen saturation, (p< 0.05).⑦.Through multiple linear regression analysis:OSAHS patients serum testosterone levels and sleep monitoring of AHI, longest apnea time, lowest oxygen saturation during sleep no statistical significance (p>0.05); And serum insulin, C peptide and leptin levels associated with sleep apnea hypoventilation index significantly (p<0.05) was statistically significant.Conclusion:①.There is not a direct relationship between serumlevels of testosterone and severity of OSAHS, but the serumlevels of testosteroneof may be dropped with age and obesity.②. There is a significance positively correlate on between of OSAHS patients serumlevels of insulin, C peptide leptin and AHI, There is a significance negatively correlate on between of OSAHS patients serumlevels of insulin, C peptide leptin and lowest oxygen saturation, Indicate obstructive sleep apnea hypopnea syndrome serumlevels of insulin, C peptide leptin the higher the more severe the disease,the determination of serum insulin、C peptide and leptin levels can be used as evaluation index of OSAHS illness severity.