| Objectives:The experimental group patients with cirrhosis of chronic hepatitis B were Child-pugh grade, at the same time, with the 256-slice CT experimental group and the control group hepatic perfusion imaging, to obtain perfusion parameters. Analysis of correlation Child-pugh grading and perfusion parameters using statistical methods to reveal the existence of links between the two. Child-pugh expect on the basis of classification, the Co-CT hepatic perfusion imaging, can compensate for Child-pugh classification of defects, liver reserve function more accurately and comprehensively assessed.Methods:Press the inclusion and exclusion criteria for selecting the experimental group and the control group.48 patients with chronic hepatitis B patients with cirrhosis were enrolled in the experimental group Child-pugh grade, the grading criteria involving a total of five indicators, including albumin, total bilirubin, prothrombin time, ascites and hepatic encephalopathy, may rely on conventional laboratory tests and physical examinations and other means of access. At the same time, respectively, in the experimental group and control group 256-slice CT hepatic perfusion imaging, to obtain perfusion parameters, including total liver perfusion, portal perfusion, hepatic arterial perfusion, hepatic perfusion index and peak time. By means of statistical methods for processing of perfusion parameters, analyze the correlation Child-pugh grading and perfusion parameters.Result:1. The total hepatic blood flow:the control group during the normal range, the control group> experimental group, the experimental group of Child A> B grade> C grade, P=0.001, statistically significant, and the Child classification in each group and the control group There was statistically significant; portal vein perfusion:the control group in the normal range, the control group> experimental group, the experimental group Child A grade> Grade B> C grade, P=0.001, statistically significant, and the Child and grade each group the control group was statistically significant, while the portal vein perfusion experimental group Child C class have the optimal threshold for 33.77ml/min/100ml; hepatic arterial perfusion:the control group in the normal range, Child A class<class B<control Group<C grade, P=0.070, not statistically significant; hepatic perfusion index:control group Child C level> B grade between the normal range, the control group <experimental group, the experimental group> A grade, P=0.001, having statistical significance, and Child C grade were statistically significant and A grade, B grade and the control group, the relative ratio of the other two was not statistically significant.2. abdominal aortic peak time: the control group in the normal range, the control group <experimental group, P=0.139, not statistically significant; liver peak time:the control group in the normal range, the control group <experimental group, P=0.001 There was statistically significant; spleen peak time:the control group in the normal range, the control group <experimental group, P=0.001, statistically significant; portal peak time:the control group in the normal range, the control group <experimental group, P = 0.001, statistically significant.3. The different experimental groups right hepatic lobe size of the lower three concentric ROI, total liver perfusion:Group> Group B> Group C, P=0.996, not statistically significant; portal vein perfusion:Group> Group B> Group C, P=0.955, not statistically significant; hepatic arterial perfusion:Group <Group B<Group C, P=0.902, not statistically significant; hepatic perfusion index: Group <Group B<Group C, P=0.879, not statistically significant.Conclusions:1. The total hepatic blood flow, portal venous perfusion lower than the control group, Child-pugh score higher total hepatic blood flow, lower portal venous perfusion. And those of the portal perfusion≤33.77ml/min/100ml of Child C patients with a preliminary assessment of hepatic arterial perfusion grade 2. Child A grade lower than the control group, but the Child A grade -Child C-class exhibits progressively increased changes, Child C group compared with the control group, hepatic arterial perfusion and Child-pugh classification is not associated with 3. liver perfusion index higher than that in the control group, Child-pugh score higher, HPI 4. the higher the peak time in the abdominal aorta artery compared with the control group had no significant change, while in the liver, spleen and portal vein than in the control group were prolonged 5. The right hepatic lobe under different sections of concentric circles the size of the three groups of interest, various perfusion parameters changed little. Accordingly, Child-pugh grade joint 256-slice CT perfusion imaging may be chronic liver cirrhosis liver reserve function in patients with more comprehensive and accurate assessment. |
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