Clinical Study Of Chronic Osteomyelitis Treated With Vancomycin-calcium Sulfate

Chronic osteomyelitis is mostly by acute osteomyelitis evolved, may have a sinus tract and festering drainage for a long time, the course can be in delay for decades, or even a lifetime not more, to stimulate the surrounding skin antrum long-term solutions, also can happen squamous cell carcinoma, is a headache for orthopedic surgeons feel and great pain to the patient’s disease. Although at present there are a lot of clinical cure Treatment method, but the treatment effect is not very ideal, can cause serious disability and dysfunction of the limbs, amputation and even life threatening. As a result, chronic osteomyelitis is still a modern orthopedic surgeons must face a major challenge.Purpose:Evaluating the effect of vancomycin of calcium sulfate in the treatment of chronic osteomyelitis.Materials and method:Select shandong province hospital of orthopaedics in January 2012- December 2013 were analyzed in 40 cases of chronic osteomyelitis. 12 cases treatment group: male, female 8 cases; The age of 35 to 60 years old, the average age of 52. Infection: 6 cases of femoral and tibial 13 cases, heel bone in 1 case. Six cases of blood-borne osteomyelitis, repeated infection in delay does not lead to chronic osteomyelitis, there is no history of internal fixation, debridement surgery; 14 cases of traumatic fracture internal fixation for postoperative infection, infection after take out for debridement, internal fixation surgery such as transferring myocutaneous flap coverage. Infection duration on July 8 years. All cases radical debridement, removing dead bone and granulation tissue after implantation of vancomycin calcium sulfate. Control group: 14 cases of male, female 6 cases; Average age 38-62, 51 years old. The infection: femur in 5 cases, 16 cases of tibia. 5 cases of blood-borne osteomyelitis, without internal fixation and debridement history; 15 cases of traumatic postoperative infection. Infection course of 7 to 10 years. All cases of complete debridement gentamicin bone cement filling after treatment.Conclusion :Treatment group 20 cases, total effective cases 19 cases, the total effective rate was 95%; Control group 20 cases, total effective cases in 16 cases, total effective rate 80%, all cases were followed up for 6 months to 2 years, 3 cases of treatment group recurrence, the recurrence rate 15.8%, control group 4 cases of recurrence, the recurrence rate 25%, two groups of data on statistical processing have significant difference(P < 0.05), suggesting that load vancomycin artificial bone calcium sulfate in the treatment of chronic osteomyelitis of the gentamicin PMMA, can obviously reduce the recurrence rate.