Research On The Design Of Scaffolds Microstructure For Composite Structure Artificial Bone

The structure of bone tissue engineering scaffold determines the osteogenesis performance of the artificial bone, therefore scaffolds not only requires 3D microstructures and must have sufficient strength. Aimed at the difficulties, this paper conducted a numerical simulation research, studying the effect of the microporous structure of the artificial bone scaffolds on the stress, strain and deformation by using finite element analysis software. At the same time, the mechanical compression experiment of artificial bone scaffolds structure was used to analyze the mechanical performance.The microporous structure was optimized designed for the artificial bone scaffolds of biological ceramic β-tricalcium phosphate(β-TCP). The three-dimensional models of scaffolds with microporous structures were established by using ANYSYS software, and gave it the boundary conditions, loading conditions, material parameters, and then meshed it. The design parameters and range was defined, the multi-objective optimization analysis on the scaffolds model was studied. The relationships between porosity and maximum equivalent stress, and the maximum total deformation were calculated. The effects of microporous spacing and diameter on the maximum equivalent stress, the maximum total deformation and the internal strain were compared and analyzed. The greater the porosity and the proportion of the best strain range, the smaller the maximum equivalent stress and the maximum total deformation, the better the biological and mechanical properties of scaffolds was. The influence laws of microporous parameters in all directions on the porosity, the maximum equivalent stress, the maximum total deformation and the internal strain were obtained by analyzing. These results provided a meaningful reference value for the design and optimization of the scaffolds structure.The optimization design on the titanium alloy scaffolds was carried out for the previous research of distribution of the compound structure of titanium alloy. The titanium alloy scaffolds models with different microporous spacing and diameter structures were established, and the finite element analysis was carried out, in order to extract the maximum equivalent stress and the maximum total deformation of scaffolds. At the same time, the titanium alloy scaffolds structure was formed by the Selective Laser Melting technology(SLM), and mechanics experiment was used to validate the results of simulation. Results showed that the increasing of the Z axis diameter and X axis layer of titanium alloy is more advantageous to increase mechanical properties of the scaffolds.The internal structure of biological ceramic and titanium alloy composite structure of artificial bone scaffolds was designed, and the influence laws of the distribution and diameter of titanium alloy in compound structure on the mechanical behavior of scaffolds were analyzed. The finite element models of compound structure scaffolds with different distribution and diameter of titanium alloy were established by using ANYSYS software, and the maximum equivalent stress, the maximum total deformation were calculated. Results showed that the greater the stress area of titanium alloy in the composite structure,the smaller the maximum equivalent stress and the maximum total deformation, and the better the biological properties and the mechanical properties was. The influence laws of microporous parameters of titanium alloy on the maximum equivalent stress and the maximum total deformation were obtained by analyzing. These results provided a meaningful reference value for the design and optimization of the scaffolds structural.