Correlation Studies On A Clinical Follow Up Study Of 0 To 2-year-old Infants Early Breast Development

Purpose:807 cases of infants with premature thelarche,who visited the department of endocrinology in our hospital from April 2012 to March 2013,were followed up.And analyze the possible related factors,we aimed at finding the effective measures to prevent and cure the phenomenon in infants through the study.Methodology:1. 807 infants under two years of age who were diagnosed with PT(premature thelarche) in Jiangxi Children ’ s Hospital during Apirl, 2012 to March, 2013 are selected as subject investigated.2.Adopt “follow-up”surey The first visit of history-taking had finished from Apirl 2012 to March 2013,follow-up was made every three month after first visit until three-year-old.3. Compare the basic of sex hormone level of fade infants and unfade infants;4. Compare the related factors of fade infants and unfade infants;5. Compare the estradiol levels before and after follow-up。6. And rank test,logistic regression analysis are employed into the results.Result:1. There are 41(7.2%) cases of PT infants at 0-3 months,389(67.9%) cases of PT infants at 4-12 months,143 cases of PT infants at 13-24 months in 573 cases of follow-up infants.The majority(88.8%) of infants can fade gradually,the average age is 16.6±8.3months,11.2% had recurrent or persistent thelarche,only minority turn into precocious puberty;2. Basic sexcual hormone determination The basic value of Follicle-stimulating hormone(FSH),Luteinizinghormone(LH),Estradiol(E2),prolactin(PRL),progesterone(P)has no statistical significance with the regression of premature thelarche(P>0.05).While the Basic value Estradiol(E2)has statistical significance with the regression of premature thelarche(P=0.03).3. In related risk factors family near polluting factories, the relationshipbetween the couple is not good,monther early age at menarche,high frequency use of plastic Products(bottles,tableware,toys,food packing materials,et al.) often eat animal food,drinks,puffed food sucker pigmented foods containing preservatives,feeding patterns(formula feeding,mixed feeding),which are related with the prognosis of the premature thelarche infants(P<0.05).4. Compared the level of serum estradiol at first to further consultation,the estradiol level increased or not were closely and the tanner stange of breast at first visit are related to the regression of infants with Premature thelarche(P<0.05).Conclusion:Most of them can fade.Premature thelarche under two-year-old infants do not fade away is related to levels of estradiol at first visit,high-protein diet and environmental pollution.