| Objective: The different levels of iron status in the body may result in different hematological characteristics, it can also bring a huge challenge to health. This study aimed to analyze the changes in clinical hematology and states of health in the iron overload adult population, and to provide a reference on iron overload effects on human health and chronic disease prevention for further research.Method: The objects were randomly selected from physical examination people in a hospital in 2014. Based on the different levels of serum ferritin concentration,we categorized people into iron normal groups(male:15~200μg/L;female:15~150μg/L)and iron overload group(male:>200μg/L; female:>150μg / L).113 normal iron status and 124 iron overload people were included in the study,and the age range was 40-70. Fasting blood were collected. Blood biomarkers such as hemoglobin, serum iron, peripheral blood cells, liver function and mineral levels, etc were tested and comparative analyzed. Result: The average hemoglobin level of iron overload group(156.16g/L)was higher than normal group(147.76g/L,P<0.001). The average red blood cell count level of iron overload group(5.01×1012/L)was higher than normal group(4.83×1012/L,P<0.001),and hematocrit, mean corpuscular volume, mean corpuscular hemoglobin of iron overload group were significantly higher than normal group(P<0.05).The serum iron of iron overload group(22.93 μmol/L) was significantly higher than normal group(17.83μmol/L,P<0.05).The transferrin saturation of iron overload group(36%) was significantly higher than normal group(28%, P<0.05).The unsaturated iron binding capacity levels and transferrin concentration of iron overload group were significantly lower than normal group, total iron binding between the two groups was not statistically significant difference(P> 0.05). serum protein level analysis showed that the total protein concentration of iron overload group(76.02g/L) was significantly higher than normal group(73.64g/L,P<0.05),albumin concentration of iron overload group(44.83g/L) was significantly higher than normal group(43.55g/L,P<0.05). Elemental analysisshowed that average serum calcium level of iron overload group(2.42mmol/L)was significantly higher than normal group(2.39mmol/L,P<0.05), serum selenium levels(51.23μg/L) was significantly higher than normal group(37.21μg/L,P<0.05); and serum sodium, potassium, magnesium, chromium, nickel, cadmium, manganese, copper, zinc ion concentration between the two groups showed no significant difference(P>0.05). Health physical analysis showed that the BMI of iron overload group(26.31kg/m2) was significantly higher than normal group(25.47 kg/m2,P<0.05), systolic blood pressure and diastolic blood pressure of iron overload group were significantly higher than normal group(P<0.05). The enzyme of liver function analysis showed that the alanine aminotransferase of iron overload group(32U/L) was significantly higher than normal group(22U/L,P<0.05), the aspartate aminotransferase of iron overload group(22U/L) was significantly higher than the normal group(20U/L,P<0.05), the glutamyl endopeptidase(38U/L) was significantly higher than normal group(19U/L,P<0.05).Conclusion: The iron-related indicators were significantly higher or lower when iron excess deposition in the body. A significant increase was found in red blood cell count and volume,iron status and the enzyme activity –related liver function, and A preliminary analysis was found that iron overload often increased in high BMI index group. However, the body of excess iron deposition has caused significant changes in the body’s blood parameters, it need a further study to find out that whether potentially harmful to the body health. |
PDF Full Text Request