Evaluating Clinicopathologic Features,invasion And Proliferative Activity Of NHL With Apparent Diffusion Coefficient

Objective:To explore the relations of the ADC of relative apparent diffusion coefficient(r ADC)of clinicopathologic features, invasion and proliferation of non-hodgkin lymphoma. To analysis the value of the ADC and r ADC in diagnosis of the Malignancy of lymphoma, to explore the relationship between ADC, r ADC and ki-67, provide a new thought for the diagnosis of NHL.Materials and Methods:Collected from February 2013 to January 2014 local DWI examination(b=0,l000s/mm2) was 40 cases of patients who had been in Shanxi Tumor Hospital. Local DWI examination was performed in 40 patients with pathologically confirmed lymphoma,who received no previous treatment, male 22 cases, female 18 cases, age13-71, the average age of 51, And the statistic data were performed by the SPSS16.0 soft ware, Data of ki-67,ADC values, r ADC values, gender, age, the origin of tumor cell, whether there are general symptom or not, the primary position of lymphoma, Ann Arbor stage, malignant degree,pathological type were collected. Differences of the ADC, r ADC and clinicpathologic parameters like age, the primary position of lymphoma, malignant degree, and so on were compared using the independent-Sample t test. Receiver operating characteristic(ROC)curve analyses were performed to determine the cut-off values to ADC, r ADC and ki-67 of NHL. Analysis of ADC value, r ADC and Ki-67 positive correlation with Spearman rank correlation.Results:1.There was no statistically difference between ADC,r ADC and gender, age, the origin of tumor cell, whether there are general symptom or not, the primary position of lymphoma, clinicopathologic features(P>0.05).2.The expression rate of ADC, r ADC in NHL of early-stage(I and II)(0.635 ±0.041)×10-3mm2/s,0.506 ± 0.079, the One of advanced-stage(III and IV)(0.767 ±0.122)×10-3mm2/s,0.576 ± 0.128, early-stage and advanced-stage the difference of ADC values, r ADC value(P<0.05).3.Using the independent-Sample t test, r ADC value whether in NHL indolent and aggressive to identify statistically significant(P<0.05). By ROC curve research available high sensitivities and specificities of ADC, r ADC with cut-off value of 0.655×10-3mm2/s,0.512.4.ADC, r ADC value and negatively correlated with positive rate of Ki-67, ADC,rADC value judgment for the NHL provided a noninvasive way of detecting.Conclusions:1.The expression of ADC and r ADC in NHL have no relations with the gender,age,the origin of tumor cell, whether there are general symptom or not, the primary position of lymphoma,clinicopathologic features.2.The expression of ADC,r ADC and Ann Arbor stage in NHL is connected with Ann Arbor staging staging.3.ADC values may indirectly reflect the level of the malignant degree of NHL.4.There was a negative correlation between ADC, r ADC and ki-67,ADC,r ADC could also be used as one reference index to the proliferative activity of NHL.Through analyzing ADC and r ADC values of NHL, it also reflect Clinical Stage and malignant degree in NHL, then can provide proofs to judge the prognosis.