Prognosis Of Neck Residue And Recurrence Of Nasopharyngeal Cancer After Radiotherapy

Objective:To analyse the effect on prognosis of neck residue and recurrence of nasopharyngeal cancer after radiotherapy.Methods: A retrospective analysis was carried out to review the histopathological data from 58 patients with neck residue and recurrence of nasopharyngeal cancer after radiotherapy who recieved medical retreatment. The influence factors for prognosis of neck residue or recurrence patients were evaluated in a model that included the following factors: Sex, age, histological type, residual or recurrent lymph node size, the number of side involvement, regional lymph node involvement, recurrence interval, distant metastasis, clinical stage, chemotherapy, radiotherapy relapse again. Cox model were used for the analysis.Statistical analysis of survival of patients with neck residues and recurrence was performed using Kaplan-Meier method.Results: In the univariate analysis, it was confirmed that the distant metastases and recurrence intervalcorrelated to prognosis. In the COX model analysis, the significant factors were Residual or recurrent lymph node size, whether involving â…¤ area, recurrence interval and distant metastasis, recurrence after radiotherapy again(P<0.05). Kaplan-Meier analysis showed that overall survival rates of 58 NPC patients with neck residues and recurrence who received re-treatment were 82.8% at 1 year, 48.3% at 3 years, 36.6% at 5 years, respectively. 58 patients relapsed again underwent radiotherapy and 50 cases, accounting for 86.2% of the total, were using Kaplan-Meier survival analysis method displays 3-year survival and 5-year survival rates were 38.8%, 18.4%. 58 patients, the recurrence interval of less than 3 years 20 cases, 34.5% of the total number, Kaplan-Meier survival analysis method 5-year survival rate of 10.8%, the recurrence interval of more than 3 years, 38 cases, accounting 65.5% of the total number., Kaplan-Meier survival analysis method show 5-year survival rate of 39.5%.Conclusions:Recurrence interval and distant metastasis are critical factors of cervical lymph nodes after radiotherapy for residual or recurrent prognosis, and residual or recurrent lymph node size, whether involving areaâ…¤, relapse after radiotherapy again is an important factor affecting the prognosis. After residual cervical lymph node radiotherapy or radiotherapy in patients with relapse can improve survival. Prognosis of recurrence interval of more better than three years was significantly higher than in patients with recurrence intervals of less than 3 years.