| Object: To discuss the urine iodine level of pregnant women in urban areas of Shihezi, and make more scientific theory for the prevention of iodine deficiency disorders(IDD). Make a preliminary discussion between the urine iodine of pregnant woman and thyroid function, thus reducing the prevalence of thyroid disease in pregnancy. And make a better implement on the advocating of eugenic policies.Methods:1. 610 pregnant women were randomly selected from January 2014- October 2014 in the first affiliated hospital of Shihezi University,who were doing prenatal examination or were about to delivery, they all live in Shihezi region more than 5 years, the age was from 19 to 45(28.64±4.94 years). Meanwhile,130 healthy people were randomly selected in our hospital from the Physical Examination Center, the age was from 18 to 48(27.61±4.23 years).2.The arsenic cerium digestion principle on automatic biochemical analyzer was used to analysis the urinary iodine from pregnant women. The measurement of thyroid function was on automatic micro particle chemiluminescence analyzer which was made from Beckman company.3. The nonparametric test was selected to analyze the iodine nutritional status from the selected pregnant women. Different locals, education backgrounds and ages were analyzed between the pregnant women. Chi-square test method was used to analyze the incidence of thyroid diseases during pregnancy in the pregnancy duration groups and the iodine nutritional status groups. P<0.05 was taken as statistically significant.Results: 1.The urine iodine level of 610 pregnant women was between 25.6μg/L and 1084.2μg/L, and the median was 180.0μg/L. In the study, the number of the pregnant women in different education backgrounds groups and from different locals groups whose urine iodine levels are lower than 150μg/L, are less than 50%. On the iodine deficiency rates, significant differences were found in different education backgrounds groups and from different locals groups(P>0.05);but there were no significant differences found in the different age groups and the pregnancy duration groups(P>0.05). 2. In different periods of the pregnancy, the levels of TSH are all lower than non-pregnancy group. Obvious differences were found between the pregnancy of T1 group and non-pregnancy group, T2 group, T3 group(P>0.05). There was no statistical significance between non-pregnancy group and T3 group. About the level of FT4, there were no significant differences between T1 group and non-pregnancy group, and also among T1 group, T2 group, T3 group(P>0.05). Significant differences were found between non-pregnancy group and T2 group, T3 group,(P<0.05).During the pregnancy, small changes happen on the level of FT3. There were statistical significance between T3 group and non-pregnancy group, T1 group. 3. Total prevalence rate of clinical hypothyroidism, subclinical in pregnancy and low serum T4 syndrome are 1.3%, 5.2% and 1.6%. There were no significant differences found among iodine deficiency group, iodine adequate group, more than adequate and iodine excess on the sides of clinical hypothyroidism, subclinical in pregnancy and low serum T4 syndrome(all P>0.05).Conclusion: Pregnant women’s iodine nutritive level in Shihezi region is adjusted to an optimum level. We should make the urinary iodine monitoring in real time. The rate of iodine deficiency is irrelative with periods of the pregnancy and the pregnant women ages, but is relevant to education backgrounds and live places. There is a U shaped curve between the state of nutrition during pregnancy and prevalence rate of subclinical hypothyroidism and low serum T4 syndrome. The state of iodine deficiency and excess will increase incidence of subclinical hypothyroidism and low serum T4 syndrome. |
PDF Full Text Request