Preparation Of Starch/polyethylene Oxide Nanofiber Membrane And Its Drug Loading Property

This study choose the water slightly soluble drug ibuprofen(IB) as a model, poly ethylene oxide(PEO) and corn starch(ST) as the carrier,and the electrospinning method was chose to prepare the IB/PEO/ST nanofiber membrane. This study expected to obtain the drug loaded fiber membrane that drug release rate can be controlled artificially. At the same time, the bioavailability can be increased, and it was better applied to clinical treatment. Nano fiber morphology and particle size distribution were observed by scanning electron microscopy. Molecular interactions were studied by infrared spectroscopy and X- ray diffraction. Drug release time and cumulative release rate in drug loaded nanofibers were measured by vitro experiments. The results were as follows:1.Spinning process was relatively smooth when PEO concentration of the solution was 5%,smaller diameter and uniform distribution nano fiber membrane were observed by scanning electron microscopy, the average fiber diameter was 223 nm, and no adhesion and beaded phenomenon appeared.2.Under the condition of the total concentration of solution was 5%,the voltage was 8KV, the diameter of nano fiber was reduced as the proportion of ST increased,the diameter of nanofibers reduced,while nano fibers adhered,thickness degree was uneven and the urface was not smooth,and appeared starch granules., A relatively uniform fiber diameter distribution and smooth surface were obtained under the condition of and the proportion of PEO and ST was 4:1 and 3:2.3.Maybe there was interactions of hydrogen bonds among ST,PEO and IB molecules by the analysis of IR spectra.4.X-ray diffraction pattern showed that IB will be combined well with the composite fibers when the drug loading be 1% and 2%.5.The vitro dissolution experiments showed that Drug release time increased as the amount of drug loaded in nanofibers increased, drug release rate could reach 100%. If the mass fraction of ST increased, the rate of drug release accelerated, the time the drug release shorted under the same condition.