Applied Value Of Diffusion Tensor Imaging(DTI) In Combination With Proton Magnetic Resonance Spectroscopy(~1H-MRS)in Encephalopathy Of Prematurity

Objective:Discussion 3.0T MRI diffusion tensor imaging(DTI) combined with proton magnetic resonance spectroscopy(1H-MRS) technique using the value of the deep gray nuclei injury in encephalopathy of prematurity(EP), in order to improve the understanding of the disease and provide reliable basis for clinical treatment and prognosis evaluation.Materials and methods:Collected by the clinical and imaging diagnosis of corrected gestational age encephalopathy of prematurity(EP group) patients 22 cases and normal newborns 22 cases as control group.On two groups of subjects were performed routine 3.0T magnetic resonance imaging scans(including DWI), expansion tensor imaging(DTI),proton magnetic resonance spectroscopy(1H-MRS) examination.EP group and normal control group DTI ROIs are deep gray matter nuclei(caudate head, globus pallidus, putamen, ventral lateral thalamus, red nucleus, substantia nigra, 6groups).EP group and the normal control group 1H-MRS region of interest for the deep gray nuclei(caudate head, putamen, ventral lateral hypothalamus, 3groups).Measuring the corresponding region of interest of FA values, ADC values,Glx / Cr value, Lac / Cr value, NAA / Cr value and Cho / Cr values, Not only between intra-class and interblock were statistically analyzed,but also to study the deep gray nuclei(caudate head, putamen, thalamus ventrolateral group 3) DTI parameters and 1H-MRS metabolite ratios between the various correlations,the same as observe the changings of peak values two experimental groups each region of interest of NAA peak,Cho peak,,GLx peak,Lac peak.Results:(1)DTI:EP group head of caudate nucleus, globus pallidus, putamen, thalamus,the ventrolateral area FA value down, compared with the control group ADC values higher than normal control group,the difference of ADC values,FA values werestatistically significant(P < 0.05) between the two groups,and the red nucleus,substantia nigra FA values, ADC value is not very different between the two groups,the difference was not statistically significant analysis(P> 0.05).(2)1H-MRS:EP group caudate head, dorsal thalamus, putamen NAA / Cr decreased compared with normal control group, Cho / Cr, Lac / Cr, GLx / Cr values higher than those in the control group,Statistics metabolite ratio difference between the two groups were statistically significant(P < 0.01).(3)Correlation analysis of two experimental datas:Head of the caudate nucleus,putamen, thalamus ventrolateral three parts of FA values corresponding parts Cho /Cr, GLx / Cr, Lac / Cr ratio was negatively correlated(r <0, p <0.05), and NAA / Cr The ratio was positively correlated(r> 0, p <0.05);but ADC values and the corresponding parts of the corresponding parts of Cho/Cr, that GLx/Cr, Lac/Cr ratio exists positive correlation(r > 0, p < 0.05), the negative correlation with NAA/Cr ratio(r < 0, p < 0.05).Conclusion:(1)DTI in combination with 1H-MRS inspection technology,not only can effectively show EP damage the deep gray nuclei for diagnosis and evaluation,but also verify the pathogenesis of the damage from the structural and metabolic aspects of deep-seated,to make the diagnosis of EP standard more clearly, to know more comprehensive, redesign of clinical treatment and prognosis assessment provides a more comprehensive guidance, has important clinical significance and broad application prospect of research.(2)EP group head of caudate nucleus and putamen, thalamus ventrolateral FA value was positively correlated with NAA/Cr,and was negatively correlated with Cho/Cr、Glx/Cr、Lac/Cr;but the corresponding area of the ADC values was negatively correlated with NAA/Cr and Cho/Cr, and was positively correlated Glx/Cr、 Lac/Cr.(3)The red nucleus, black qualitative development of children with EP may not be affected.