| Objective: To determine the association between normocalcemic primary hyperparathyroidism(NPHPT) and blood pressure.Methods: We retrospectively enrolled 940 patients who visited at Fujian Provincial Hospital between September 2010 and December 2013 with a measured serum parathyroid hormone(PTH) and calcium level. Among them, 11 patients were diagnosed with NPHPT, while 296 cases with normal PTH and albumin-adjusted serum calcium. Body mass index(BMI), systolic blood pressure(SBP), diastolic blood pressure(DBP), intact serum PTH, serum calcium, fasting plasma glucose(FPG), triglycerides(TG), total cholesterol(TC), high density lipoprotein(HDL), low density lipoprotein(LDL) and serum creatinine(Cr) were recorded. Differences between categories were tested by one-way ANOVA, χ2 and nonparametric tests as appropriate. Logistic regression models were applied to adjust for potential confounders.Results: There were no significant differences between subjects identified with NPHPT and those with normal PTH in terms of age, sex, BMI, serum calcium, 25-Hydroxyvitamin D, serum creatinine, FPG, TG, TC, HDL and LDL. The subjects with a diagnosis of NPHPT had higher levels of SBP(141.9±20.2 vs 131.2±16.5, P = 0.041) and DBP(85.2±12.4 vs 76.8±10.3, P =0.026) than the subjects in the cohort with normal PTH. After adjustment for all potential confounders, risks(odds ratios and 95% confidence interval) of SBP and DBP in NPHPT patients were 1.035(1.000, 1.071) and 1.063(1.004, 1.125), respectively(P < 0.05).Conclusions: The NPHPT had higher risk of high blood pressure than subjects with normal PTH. It is worth considering the necessity of more aggressive therapeutic intervention aimed to normalize PTH even if patients with NPHPT continue to be normocalcemic. |
