Nine Kinds Of Pathogenic Examination Situation Analysis Of Respiratory Tract Infection

Objective: To detect the respiratory pathogen and oxidative stress indicator in patients of respiratory tract infection and analyze its infections status, epidemiological feature and relationship with oxidative stress of respiratory tract infection, which could provide reference and new ideas for clinical medical. Methods: 1898 samples from hospitalized patients with respiratory tract infection during January to December in 2014 in The First Affiliated Hospital of Medical College of Shihezi University were recruited, and IgM antibody of common respiratory pathogens were detected by indirect immuno-fluorescence assay. Then its distribution and popular features related to sex,age and season were viewed. The cases were divided into COX group, MPP group and SMPP group according to the detection results and the severity of disease. And the healthy persons in the same period were served as the control group. Then the level of SOD and NO in each group were detected, and the relationship of SOD and NO in each group respectively were analyzed. Results:(1) The IgM-positive rate of 1898 cases was 24.76%, and MP-, COX-, LP1-, CP-, INFB-, PIVs-, RSV-positive rate was 15.17%, 5.59%, 3.16%, 2.74%, 2.11%, 1.16%, 0.53% respectively.(2) In the 98 cases of mixed respiratory tract infection, MP and COX combined with other pathogens were major. There were 10 cases which were more than two kinds of pathogens mixed infection.(3) The positives rate of younger than 14 year old people was 30.75%, and MP was 23.63%. MP-positives rate of women was higher than that in men(P<0.05). IgM-positives rate of adults was 20.8%, and COX was 7.3%. The COX-positives rate of men was higher than that in women(P<0.05).(4) MP showed the highest positives rate(32.79%) in April, and COX showed higher positives rate in March, April, May, June and July, the positives rate was 11.43%, 8.20%, 10.79%, 8.67% and 9.09% respectively.(5) Compared with the normal group, the level of SOD and NO increased in MPP group, the level of SOD decreased and NO was increased in SMPP group(P<0.05). Compared with MPP group, the level of SOD in SMPP group decreased and NO was increased(P<0.01).(6) Compared with normal group, the level of SOD and NO in COX group increased(P<0.05). Conclusions:(1) MP was the main respiratory tract infection pathogen, and the positive rate was the highest in April. Its infection was more in children; COX was the main respiratory tract infection pathogen in adults, and the positive rate was higher in spring; There were also mixed infection with respiratory pathogens.(2) SOD and NO plays an important role in respiratory tract infection, MP and COX infection could cause oxidative stress reaction, and severe infection could lead to oxidative stress damage.