Analysis Of 19 Cases Of Invasive Tracheobronchialaspergillosis In Non-neutropenic Patients

Objective:To enhance the recognition of diagnosis and treatment of invasive tracheobronchial aspergillosis in non-neutropenic patients.Methods:The clinical data of 19 cases of ITBA in non-neutropenic patients were collected and retrospectively studied.ResultsThe average age of subjects was (57.32±11.69) years with 6 female and 13 male. The complicated with underlying diseases included the chronic obstructive pulmonary disease (COPD) (21%), diabetes(21%), lung tumor (16%), hypertension(16%), pulmonary tuberculosis (11%), vasculitis angeitis angitis (5%) and interstitial lung disease (5%); The clinical manifestations included intensive breathlessness, dyspnea and amyctic cough hemoptysis. Radiographic findings were only revealed slight abnormal at the beginning of the ITBA. The preferred drug for treatment is voriconazole. The total course of more than 6 weeks, the longest 22 weeks. Among them 1 case for economic reasons 4 weeks after treatment to drug withdrawal,8 weeks after again because of new lesions was observed in the lung disease progression readmission.Conclusion:Aspergillus tracheobronchitis is a rare form of invasive pulmonary aspergillosis. ITBA in non-neutropenic patients is often misdiagnosed. Physicians should therefore consider Aspergillus tracheobronchitis as a possible diagnosis in non-neutropenic patients presenting with atypical respiratory symptoms and should attempt a prompt diagnosis with a procedure such as bronchoscopy.