| Objective:To investigate the level of peripheral B-type natriuretic peptide (BNP) and troponin I (cTnl) before and after treatment in children with congenital heart disease complicated with pneumonia, illustrate the correlation between the two factors and heart failure levels, and make sure whether they could be indicative factors for therapeutic evaluation.Methods:73 cases in our hospital with pneumonia and congenital heart disease children patients from February 2014 to September 2015 were admitted into this research, including 38 cases of heart failure with congenital heart disease complicated with pneumonia (HF group).35 cases without heart failure, but with congenital heart disease complicated with pneumonia group (NHF group).heart failure group were divided into three subgroups:mild heart failure group, moderate heart failure group and severe heart failure group.30 cases of pneumonia were treated as control group at the same period (CP group).The following tests and examinations were prepared:, BNP, cTnl, ECG, X-ray and echocardiogram etc. The level of peripheral BNP and cTnl before and after treatment were detected.Results:1.Peripheral BNP concentration of HF group patients was significantly higher than N-HF group and the CP group (397.89±194.89 pg/ml vs 49.06±17.55pg/ml, 397.89±194.89 pg/ml vs 46.13±19.58pg/ml) (P<0.01), the latter two groups showed no significant difference (49.06±17.55 pg/ml vs46.13±19.58 pg/ml) (P>0.05).2.In cTnI concentration analysis, the cTnI level of HF group patients was significantly higher than N-HF group and the CP group(0.059±0.017 ng/ml vs 0.024±0.016 ng/ml, 0.059±0.017 ng/mlvs0.023±0.016 ng/ml) (P<0.01), the latter two groups showed no significant difference (0.024±0.016 ng/ml vs 0.023±0.016ng/ml) (P>0.05).3. The peripheral BNP and cTnI concentrations were significantly higher HF group of children with severe heart failure than those with moderate heart failure group, which was significantly higher than mild heart failure,BNP (244.29±74.46 pg/ml vs 425.33±77.40 pg/ml vs 764.50±42.87 pg/ml, P<0.01), cTnI(0.050±0.015 ng/ml vs 0.065±.008 ng/ml vs 0.086±0.016 ng/ml, P<0.01)4. Concentration of peripheral BNP and cTnI HF group was significantly lower in recovery stage than in the acute stage,BNP(48.88±20.61 pg/ml vs 329.15±118.95 pg/ml, P<0.01), cTnl (0.028±0.008ng/ml vs 0.054±0.013ng/ml,P<0.01)Conclusion:1. Concentrations of BNP and cTnI were significantly increased in HF group, positively correlated with the severity of heart failure, which can be used as an effective biomarker for heart failure evaluation.2. Concentrations of BNP and cTnI were significantly lower in HF recovery stage than in the acute stage, indicating these factors can be used as effective indicators of therapeutic efficacy. |
