The Study Of Rapid Release Tablets Of Radix Puerariae Flavones Based On Liquisolid Technique

Radix Puerariae flavones is the general term of flavonoids extracted from Radix Puerariae. It mainly treats cardiovascular and cerebrovascular diseases.But the poor water solubility limits its oral absorption and results in low bioavailability. The current improvement in drug dissolution methods has certain limitations: for example, long time storage of solid dispersion preparation will appear the phenomenons of aging, decreases of crystallization and dissolution. Cyclodextrin inclusion technology have restrictions on the size of guest molecules and the low solubility in water. This paper used Liquisolid technique to improve the dissolution rate of Radix Puerariae flavones and release the drug rapidly. Then it was prepared into the liquisolid tablets.Firstly, this paper had quality control study of Radix Puerariae flavones investigated by the shape, TLC identification, inspection, Determination of content and respectively established UV and HPLC methods to determin Radix Puerariae flavones and Puerarin from crude drug.And it established the method of determining release degrees of drug in vitro,which laid the foundation for the future prescription screening and the evaluation of the quality of preparation.Radix Puerariae flavones was prepared into liquisolid tablets. And the paper selected different liquid vehicles, carrier and coating materials, ratios of the drug in solution, R values and additives.And it investigated different influences on drug release from different PVPK30 concentrations, the concentration of drug solution and Liquisolid technique,which had selected the best prescription of liquisolid compression and verificated it.Properties of liquid solid compression system was studied.This paper examined the properties of the drug solution, powder and liquisolid tablets by the determination of viscosity, DSC, powder wettability determination,the tablet quality evaluation and dissolution determination,which were as analysis tools to explore the solubilization mechanism of liquisolid technology from different aspects. And the selection of magnesium aluminium silicate as a carrier and coating materials, by increasing the Lf value, improved the loading capacity of Radix Puerariae flavones.Then,the paper had quality control study of liquisolid tablets.It mainly investigated the shape, TLC identification, Determination of content and the critical relative humidity and respectively established UV and HPLC methods to determin Radix Puerariae flavones and Puerarin from liquisolid tablets.Finally, the solubilization mechanism of Liquisolid technique were discussed.It explained the solubilization mechanism respectively from three aspects of increasing the drug solubility, increasing the drug surface area and improving wetting properties of drug powders.And it summarized the effects of additive (PVPK30) in the Liquisolid technique:the decrease of tablets weight, enhancement of powders flowability and the development of wetting properties of liquisolid powders.