A Meta-analysis Of Risk Factors Of Para-aortic Lymph Node Metastasis In Cervical Carcinoma

Objective: To analyze the risk factors of para-aortic lymph node metastasis in cervical carcinoma by the method of Meta-analysis.Method: Pubmed database, Elsevier,Wiley, CBM, CNKI, Wanfang database and VIP database were searched. After abandoning the studies do not fit the qualification, the risk factors of para-aortic lymph node metastasis in cervical carcinoma were assessed by Meta-analysis according to the inclusion criteria. All data were processed and Review manager 5.3 software was used for statistic analysis.Result: 11 studies were searched with the standard of inclusion and exclusion. By the method of Meta-analysis, there was higher incidence in the groups of FIGO staging late, depth of invasion, capillary lymphatic space involvement, pelvic lymph nodes(PLNs) and common iliac lymph nodes metastasis, para-metrial invasion, bilateral PLNs metastasis, Corpus invasion, SCC-Ag>4μg/L and Hb<110g/L. And there was no significant difference in the groups of age, histology, differentiation, tumor size andpreoperative therapy.Conclusion: FIGO stage, capillary lymphatic space involvement, pelvic lymph nodes(PLNs) and common iliac lymph nodes metastasis, para-metrial invasion are risk factors for para-aortic lymph node metastasis in cervical carcinoma. Bilateral PLNs metastasis, Corpus invasion, SCC-Ag>4μg/L, Hb<110g/L are possible risk factors as only one research relates to these factors. Depth of invasion is a possible risk factor, whereas there is publication bias. Preoperative therapy can affect the detection of lymph node metastasis so that the conclusion is not exact. While age, histology, differentiation and tumor size are not risk factors.