The Relationship Between Transcutaneous Oxygen And Urinary Albumin-to-creatinine Ratio To Patients With Type 2 Diabetic Kidney Disease

Objective: To investigate the relationship of transcutaneous oxygen pressure（TCPO₂） and urinary albumin-to-creatinine ratio（ACR） of patients with type 2 diabetic kidney disease, to further clarify whether through transcutaneous oxygen can provide early kidney damage in patients with diabetes who were diagnosed.Methods: 48 patients of type 2 diabetic kidney disease were selected from October 2015 to January 2016 in the Chinese-Japanese Friendship Hospital of Jilin University Endocrine and Metabolic Diseases.There are 31 males and 17 females, aged 18 to 78 years, mean age（55.77 ± 14.35） years, history of 1 year- 35 years;Randomly selected control group equally in the Chinese-Japanese Friendship Hospital of Jilin University Endocrine and Metabolic Diseases from Oct. 2015 to Jan. 2016 type 2 diabetes who are diagnosed as non-kidney disease.There are 50 cases（31 male cases, 19 females）, aged 20 to 77 years, mean age（51.28 ± 12.84） years, history of a month to 20 years. Their diagnosis are in line with the 1999 WHO diagnostic criteria for diabetes. In the control group to exclude a variety of other etiologies of acute and chronic kidney disease. All patients in the hospital the next morning fasting measuring height and weight, to compute body mass index（BMI）, fasting blood collected glycated hemoglobin and blood biochemical indicators morning urine specimens measured ACR, urine specimens from 24 hours, take 10 ml inspection microalbuminuria after mixing it. Checking TCPO₂, ABI, TBI and fundus examination. Analysis and comparison of type 2 diabetic kidney disease group and control group TCPO₂ the relationship between ACR and various indicators, the relationship with each factors and TCPO₂ and the factors which impact TCPO₂.Results: 1, Difference between diabetic kidney disease group and control group in history, TCPO₂, ACR, MA, CREA, BUN, rate of prevalence and rate of retinopathy are significantly, P <0.05. There is no significant difference in age, sex, BMI, ABI, HBA1 C, FPG, TG, TC, H-LDL, L-LDL, P> 0.05;2, Diabetic kidney disease TCPO₂ positively correlated with TBI, ABI, HDL, rate of retinopathy, with ACR, MA, HBA1 C, history, FPG, TG, TC, LDL- C was negatively correlated, P <0.05; with age, sex, CERA, BUN and rate of hypertension was no significant correlation, P> 0.05;3, In TCPO₂ as dependent variables, medical history（years）, TBI, ABI, ACR, MA, Hb A1 c, FPG, TG, TC, HDL-C, LDL-C, retinopathy was a multivariate linear regression analysis shows ACR, Hb A1 c, FPG, LDL-C impact on TCPO₂ statistically significant, P <0.05.Conclusion: Patients with type 2 diabetic kidney disease transcutaneous oxygen pressure and urinary albumin / creatinine ratio was negatively correlated. TCPO₂ can serve as an early sign of diabetic kidney disease, provide the basis for early renal injury in diabetic patients. TCPO₂ influential factors of ACR, Hb A1 c, FPG, LDL-C.Regular monitoring TCPO₂ in patients with type 2 diabetes, not only can prevent peripheral artery disease, but also can provide a basis for early detection and diagnosis of diabetic kidney disease.It has a very important meaning to reduce the occurrence of diabetic kidney disease, and delay its development, reduce the complications of diabetes mortality.