Clinical Curative Effect Of Thrombus Aspiration Combined With GPI In The Patients Of Acute Stemi Undergoing PCI:a Meta-Analysis

Objective To review the clinical curative effect of thrombus aspiration combined with platelet glycoprotein II b/IIIa receptor inhibitor(GPI) in the patients of acute STEMI undergoing PCI.Method The databases of Cochrane Library,PubMed,Embase,CNKI, WanFang Database and WeiPu Database were retrieved with computer for researching randomized controlled trials about thrombus aspiration combined with GPI in the patients of acute STEMI undergoing PCI. The Meta-analysis was performed by using RevMan 5.2 software after extracted the data and evaluated the quality on the basis of inclusion and exclusion criteria.Results There were totally 10 RCT included covering 1223 patients,spliting up into treatment group and control group. The results of Meta-analysis showed that compared with the control group,the incidence of major adverse cardiovascular events(MACE) (OR=0.55,95%CI:0.35-0.88,P=0.01) and no/slow reflow (OR=0.20,95%CI:0.07-0.62,P=0.005) was significantly reduced. The treatment group had improved TIMI 3 flow (OR=4.01,95%CI:2.55-6.32,P<0.00001) and ST-segment resolution(STR) (OR=2.55,95%CI:1.89-3.44,P<0.00001) in this study.Left ventricular ejection fraction(LVEF) (OR=7.22,95%CI:6.03-8.42,P<0.00001) and corrected TIMI frame count (CTFC)(OR=-11.44,95%CI:-13.48-9.40,P< 0.00001) in treatment group was obviously better than that in control group.Conclusion Thrombus aspiration combined with GPI can obviously reduce the incidence of MACE, enhance the TIMI 3 flow,improve the STR and LVEF after PCI operation and reduce the incidence of no/slow reflow and CTFC in the patients with acute STEMI.