65 HIV-negative Patients Of Pulmonary Cryptococcosis Clinical And CT Imaging Analysis

ObjectiveTo analyze the clinical and CT imaging performance characteristics of HIV negative patients of Pulmonary Cryptococcosis.MethodsWe retrospectively reviewed the clinical date of 65 patients with HIV-negative PC who were diagnosed by pathology from January 1998 to December 2013 from Sir run run shaw hospital affiliated to Zhejiang university.ResultsA total of 65 patients with HIV-negative PC have been enrolled in the study.In 65 patients with PC:male,38 cases(58.46%),female,27 cases (41.53%),The mean(±SD) age was(45.34±13.63)years(range 16 to 72 years).Most young and middle-aged onset ages 20 to 60 years old, a total of 50 cases (76.92%).33 patients with clinical symptoms,main show was respiratory symptoms,other 9 cases of chest pain,the rest symptoms no characteristic.32 cases of patients with asymptomatic at the time of diagnosis,including 2 cases was accidentally found after trauma.27 cases with underlying diseases, Presence of underlying conditions of two groups of patients with PC type image credits comparison difference has no statistical significance (P> 0.05).Images of PC showed diversity,Which can be divided into three types,including single nodule type and multiple mixed type and patchy consolidation type. With signs of PC were complex, air bronchogram appeared in 16 cases (24.62%), vacuoles sign in 12 cases (18.46%), lobulation sign in 11 cases (16.92%), halo sign in 4 cases (6.15%), air bronchograms and focal necrosis area in 10 cases (15.38%) which occured within the same lesion. Presence of underlying conditions of two groups of patients with PC,the main signs of the difference was statistical significance (P<0.05).Diagnosis way of PC, to lesion biopsy by CT-guided (43 cases) and surgical resection (21 cases), pathological diagnosis was given priority to.58 cases (89.23%) in pathological organization found focal granulomatous lesions.Conclusion1、Pulmonary cryptococcosis clinical symptoms were not typical, occasionally occurred in HIV-negative,young and middle-aged patients with asymptomatic.2、CT manifestation of PC was diversiform, often appears in nodules and flake infiltrates shadows,Lesions often distribution of lung lower lobe and periphery,and often alone lung lobe be involvement.lt has certain characteristic polymorphous lesions exists in multiple mixed type. single nodule type diagnosis difficult.3、Accompanying signs of PC were complex, halo sign of PC in the diagnosis of limited value,air bronchogram and focal necrosis area appeared in the same lesion may be a special sign of PC.