Paclitaxel-eluting Balloon For Provisional Stenting Of Coronary Bifurcation Lesion

Background:Recent researches suggest that provisional stenting with drug-eluting stent(DES) in the main branch(MB) and drug coated balloon(DCB) in the side branch(SB) might be a valuable treatment option for coronary bifurcation lesion. Several studies investigated the combination of bare metal stents in the main branch and drug coated balloons in the side branch in bifurcation lesions, but data on the combination of drug-eluting stents and drug coated balloons are scarce. We assess the safety and efficacy of provisional stenting with DES in the MB and DCB in the SB.Methods:This is a prospective, single-center study. 57 patients with bifurcation lesions underwent angiographic assessments 9 months after undergoing percutaneous bifurcation intervention with DES in the MB and DCB in the SB.Result:The procedure was successful in all patients. After the procedure the MLD increased from 0.83±0.37 mm to 2.91±0.43 mm in the MB(p<0.001) and from 1.01±0.39 mm to 1.95±0.39 mm in the SB(p<0.001). Percent diameter stenosis declined from 78.2±13.6% to 9.1±5.5%(MB, p<0.001) and from 63.7±17.6% to 9.8±3.3%(SB, p<0.001). At nine months, the late lumen loss(LLL) in the MB was 0.27±0.38 mm and 0.10±0.44 mm mm in the SB. One patient died. Two non-target-vessel myocardial infarctions and one target lesion revascularization occurred.Conclusions: The results show that the combination of DES in the MB and DCB in the SB appears to be a safe, effective and novel treatment option for bifurcation lesions.