Encapsulation Performance And Controlled Release Of Drugs Of Interfacial Click Polymerization Based Micro- And Nanocapsules

There are two parts in this dissertation.Part one is about microcapsules containing fragrance oils as active agent that were synthesized by interfacial thiol-Michael polymerization in oil-in-water emulsion. One water-soluble dithiol and four oil-soluble acrylates were used as "click"able monomers. The polymerization kinetics was studied by HPLC and 1H NMR. The size and morphology of the microcapsules were characterized by means of light scattering, optical microscope and scanning electron microscope and their thermal property was examined by TGA. The encapsulation efficiency and stability of the microcapsules were monitored at room temperature and 45℃ for one month.In general, this interfacial thiol-ene polymerization was demonstrated to be a facile and efficient approach for fragrance microencapsulation with new and stable shell materials.Part two is about modification of the emulsification procedure in part one in order to acquire a nanoscale emulsion and nanocapsules based on it, so that we can try to apply it to drug delivery systems. We changed the nonionic emulsifier Mowiol 18-88 to ionic emulsifier SDS, and the homogenization is conducted with a high pressure homogenizer instead of a high shear one, and by doing so, we obtained desired nanoscale capsules and loaded them with amiodarone, cinchonin and paclitaxel. The dosage of the monomers were shifted to achieve different thickness of the shells, and the in vitro release of Amiodarone was measured.In short, we have developed a novel biodegradable polymer system which is concise and efficient, it has shown quite some potentials in industrial and pharmaceautical applications.