Association Of The LPA Gene Polymorphism With Coronary Heart Disease

Objective:To investigate the potential association between human LPA gene and Coronary Heart Disease( CHD) in the Chinese Han and Uygur population. Methods:831Han population( 383 CHD patients and 439 control subjects) and 829 Uygur population( 513 CHD patients and 316 control subjects)were selected for the present case-control study. Both patients and participants were genotyped for the same three single nucleotide polymorphisms(SNPs)(rs1801693, rs6923877 and rs9364559) of the LPA gene by a Real-time PCR instrument. Results : In the Han population(Total, Men, Women), the plasma Lipoprotein(a) [Lp(a)] concentration of CHD patients were higher than controls.The distribution of rs6923877 in genotype and allele frequency showed significant difference between CHD and control subjects(all P<0. 05), the distribution of the GG genotype(GG vs AG+AA) was significantly higher in CHD patients than control subjects( P < 0. 05). The significance of the GG genotype between CHD patients and control subjects retained after adjustment for the plasma concentration of apolipoproteinB100(apoB) and Lp(a), the incidence of essential hypertension(EH),diabetes mellitus(DM) and smoking(Total: OR:0.570, 95% CI:0.379-0.858, P = 0.007;Men: OR:0.608, 95% CI:0.372-0.994, P = 0.047; Women: OR:0.397,95% CI:0.178-0.886,P = 0.024). In the Uygur population, three SNPs(rs1801693, rs6923877 and rs9364559)genotype and allele frequencies were no significant differences(all P > 0.05) between the CAD group and control group. Conclusion : The LPA genetic polymorphisms are associated with CHD for the Xinjiang Han population of China, the GG genotype of rs6923877 in the LPA gene might be the protective genetic marker of CHD in the Xinjiang Chinese Han population.