| Objective:To investigate the influence of focal insular glioma on risky decision-making and to verify the idea that there is causal relationship between insular and risky decision-making cognitive process.Methods:Twenty-seven patients with a localized glioma that was limited to either the insular (N=12) or non-insular glioma controls (N=15) that were evaluated in the neurosurgery clinic of the Anhui Provincial Hospital Affiliated to Anhui Medical University from March 2014 to December 2015 were considered for participation in the present study. Additionally,fifteen right-handed healthy controls (HC) were matched with the patients for age, gender, education and ethnicity. All participants had normal MRI scans and completed the Beijing version of the Montreal Cognitive Assessment (MoCA) to evaluate the basic cognitive functions. The NEO-Five-Factor Inventory was used to assess general personality traits and Raven’s Progressive Matrices was applied to estimate basic intelligence.three groups of participants were compared on a scientificly designed risky decision-making task.Results: ① Background information:there were no significant difference among the groups with regard to gender, age, education, Raven’s Progressive Matrices, MoCA scores, NEO-Five-Factor Inventory, and Self-Rating Depression Scale. ② By contrast with normal subjects and lesion controls,the bet time (BT) and report time (RT) of insular glioma patients significantly extended,and the number of bet or report failure (F) observably increased (BT1.61s,P<0.01;RT1.61s,P<0.01;F=2,P<0.01). The BT (0.70s), RT (0.69s) and F (<1) of lesion controls were not significantly different from those of healthy group with BT 0.71s,RT 0.68s and F(<1) (P>0.05).Conclusion:The results indicated that risky decision-making cognitive process of patients with insular glioma was disrupted.These data confirmed the necessary role of insular region in decision-making under risk and insular causally involved in risky decision making. |
PDF Full Text Request