Application Of Tidal Breathing Lung Function Detection In Infants With Asthmatic Bronchopneumonia

Objective Unlike the traditional tidal breathing lung function tests to check with the instruction, only need to calm, breathing without trauma, especially suitable for the determination of infant pulmonary function, has a broad prospect in the application of respiratory disease in infants, tidal breathing parameters and tidal breathing flow capacity of a gas ring(tidal breath flow volume curve TBFV, ring) can reflect the changes of lung function in children with damage to nature and extent, indirectly evaluate efficacy in children with the severity of the disease and the evaluation of drug or therapy, this study asthematoid bronchopneumonia treated tidal breathing lung function in the process to explore the application value of determination in infants with asthmatic bronchial pneumonia in respiratory lung function moisture, provide parameters basis for the diagnosis of Infantile Asthmatic bronchopneumonia accurate and reasonable treatment.Part IMethod Select November 2013 to December 2015 Affiliated Hospital of Anhui Medical University, pediatric wheezing due to bronchial pneumonia in hospitalized infants with a total of 100 cases,Healthy control group of 80 cases. Respectively when asthmatic bronchial pneumonia hospitalized acute and remission tidal pulmonary function tests before discharge were observed asthmatic bronchial pneumonia, acute and remission tidal breathing lung function parameter index, a tidal breathing flow volume loop(TBFV rings) changes in tidal breathing pulmonary function testing in children half an hour before clinical symptom severity score, the asthmatic bronchial pneumonia divided into mild, moderate, severe, relatively light, the main tidal breathing lung function parameters in children with severe correlation index difference and clinical symptom severity scores and admission tidal breathing lung function parameters indicators.Results 1.Observation group in acute phase with RR(respiratory rate) is higher than that of control group(P < 0.05), TI/TE(inspiratory time/ expiratory time), TV/kg(tidal volume/ kg), TPTEF/TE(time to tidal peak expiratory flow / expiratory time),VPEF/VE(volume at tidal peak expiratory flow /expiratory time), TEF25%(the 25%tidal volume during expiratory flow), TEF50%(the 50% tidal volume during expiratory flow) were lower than the control group(P < 0.05); PTEF(tidal breathing peak expiratory flow), TEF75%(the 75% tidal volume during expiratory flow) higher than control group, but the difference was not significant(P > 0.05). Observation group in acute phase RR higher than in remission phase(P < 0.05),TV/kg, and VPTEF/VE,TEF25%, TEF50% were lower than in remission phase(P < 0.05), PTEF, TEF75%higher than in remission phase, but the difference of no significant difference(P > 0.05).Observation group in remission phase TI/TE, TPTEF/TE, VPEF/VE, TEF25%,TEF50% were lower than the control group(P < 0.05), and the other indicators were no significant difference(P > 0.05).2. Acute asthmatic bronchopneumonia of tidal breathing flow volume loop(TBFV loop)showed maximum expiratory flow rates decreased, peak expiratory moved ahead obviously, prolongation of expiration, descending slope increases, even to the capacity of the sag axis, pattern is a stout, after admission after active treatment expiratory descending slope than on admission decreased, curve peak expiratory was evident after the shift, TFV loop variable width, exhale ring descending from volume axis.3. To TPTEF/TE and VPEF/VE as the main observation of tidal breathing lung function index, a clinical symptoms in children with acute asthmatic bronchial pneumonia severity score for light, medium, heavy moisture breathing lung function, it is found that the acute phase score for patients with mild,moderate and heavy compared with control group, the moderate and the change of the comparison between was statistically significant, but no statistical difference between medium and heavy. Asthmatic bronchopneumonia clinical symptom severity score and the main parameters on moisture breathing lung function index by the Spearman rank correlation analysis found that clinical scoring and TPTEF/TE, negative correlation VPEF/VE, and clinical scoring and VT/kg, RR, TI/TE, PTEF, TEF75 %, TEF50 %, TEF25 % no correlation.Part IIMethod Choose a December 2013 to November 2015 affiliated Anhui medical university hospital of pediatrics for asthmatic bronchopneumonia hospitalized infants and young children, a total of 80 cases, Healthy control group of 80 cases,according to the asthma predictive index, divided into asthmatic bronchopneumonia group asthma predictive index(positive group), asthmatic bronchopneumonia group asthma predictive index(negative group), respectively in the acute phase of acute phase on admission and moisture breathing lung function testing for the first time 15 minutes after atomization,remission before discharge, the 14 th day after discharge after discharge, the 30 th day after discharge moisture breathing lung function tests, comparing the difference of different moisture breathing lung function parameters and characteristics of the two groups of bronchi relaxation test.Results 1.Acute asthmatic bronchopneumonia(Asthma Predictive Index positive group) and asthmatic bronchopneumonia(Asthma Predictive Index negative group)lung function index TPTEF/TE, VPEF/VE lower than the control group, but the acute phase of two groups of TPTEF/TE and VPEF/VE decreased with no obvious differences, remission of asthematoid bronchopneumonia(Asthma Predictive Index positive group) of lung the function indexes of TPTEF/TE, VPEF/VE and acute phase compared with no significant difference(P > 0.05), Asthma Predictive Index negative group pulmonary function indexes of TPTEF/TE and VPEF/VE in acute rise, the difference was statistically significant(P<0.05), but still lower than the normal control group.14 days after discharge of asthma predictive index of negative groups TPTEF/TE,VPEF/VE were not different between the control group and the control group, but asthma predictive index of positive TPTEF/TE and VPEF/VE is still lower than the control group, 30 days after discharge of asthma predictive index of positive TPTEF/TE and VPEF/VE still not back to normal.2. Asthmatic bronchopneumonia asthma predictive index(positive group) after atomization drug absorption lung function index TPTEF/TE, VPEF/VE improved significantly before the drug absorption, the difference was statistically significant(P <0.05), asthmatic bronchopneumonia asthma predictive index(negative group) after atomization drug absorption lung function index TPTEF/TE, VPEF/VE no significant improvement before the drug absorption, there was no statistically significant difference(P > 0.05), asthmatic bronchopneumonia bronchial asthma predictive index(positive group) diastolic experiment positive rate of 73%, asthmatic bronchopneumonia bronchial asthma predictive index(negative) relaxation experiments of positive rate was21%.Conclusion 1.Asthmatic bronchial pneumonia tidal breathing lung function parameter index in the treatment of acute and remission were different variations, although clinical symptoms after remission, but TPTEF / TE, VPEF / VE has not yet returned to normal,there are still small airway obstruction.2. Asthmatic bronchial pneumonia and a tidal breathing flow volume loop(TBFV ring)before and after the treatment of acute and remission showed different change, children can determine the location and extent of airway obstruction to assess the therapeutic effect.3.Asthmatic bronchopneumonia clinical severity score and the tidal breathing lung function the main parameter index of TPTEF/TE, VPEF/VE to negative correlation,TPTEF/TE, VPEF/VE can reflect the degree of small airway obstruction, assessment of the severity of the illness and change, to provide objective basis for clinical diagnosis and treatment of the disease.4.Asthmatic bronchial pneumonia asthma predictive index(positive group) and asthmatic bronchopneumonia asthma predictive index(negative group), compared with asthmatic bronchopneumonia asthma predictive index(positive group) lung function to restore the asthmatic bronchopneumonia asthma predictive index(negative group),pulmonary function damage persist, require early intervention treatment, prevention for the development of bronchial asthma.5.Asthmatic bronchopneumonia asthma predictive index(positive group) bronchial diastolic experimental group were significantly higher than that of asthmatic bronchopneumonia, asthma predictive index(negative group), suggesting asthmatic bronchopneumonia asthma predictive index(positive group) airway reversibility degree is higher, can reflect the two groups of airway pathology physiology characteristic,provide important basis for subsequent selection of treatment options.