Analysis Of Blood Lipids And Pregnancy Outcomes Of Hypothyroxinemia During The Third Trimester Of Pregnancy

Objective: To find out whether the last trimester of pregnancy with hypothyroxinemia affects lipid profiles,maternal and neonatal outcomes and investigate the rational diagnostic criteria of hypothyroxinemia.Method: 58 individuals with hypothyroxinemia and 56 women with euthyroidism during the third trimester were analyzed.All of their delivery were carried out in maternity ward of the First Affiliated Hospital of XinJiang Medical University from September 2014 to December 2015. For all study subjects,serum FT3、FT4、T3、T4、TSH、TG、TC、HDL、LDL、Apo A1、Apo B and maternal and neonatal outcomes were collected.We analyze the difference in serum lipid and pregnant outcomes between each group, and identify determinants using correlation analysis.Results: FT3、FT4 、T3、T4 of Women with Hypothyroxinemia was significantly lower than the control group(p<0.05), but TSH between two groups was no siginificant difference(p>0.05).The BMI of Women with Hypothyroxinemia was significantly higher than the control group(p<0.05);but lipid level between two groups was no siginificant difference(p>0.05).In Hypothyroxinemia group,T3 has a negative correlation between the level of TC and HDL.Maternal and neonatal outcomes in two groups were no siginificant difference(p>0.05).Conclusion: The concentrations of thyroid hormones were not correlated with lipid profile levels and maternal and neonatal outcomes for women in the third trimester of pregnancy with hypothyroxinemia.