Changes In Serum Sost Of Postmenopausal Osteoporosis Patie Nts Treated With Chinese Herbal Medicine Which Invigorate The Kidney

ObjectiveTo compare the difference between normal postmenopausal women and pos tmenopausal osteoporosis women in the level of serum sclerostin, then we s tudy the relationship of serum sclerostin and bone mineral density. After six Months of treatment with Jinkui shenqi pills or Alendronate we evalua te the change in the level of serum sclerostin and bone mineral density a mong different groups to discuss the mechanism and the advantages of acti on of chinese herbal medicine which invigorate the kidney.MethodsSixty postmenopausal women who from the third affiliated hospital of guang zhou university of TCM were divided into three groups called treatm ent group, normal control group and positive control group. Before treatmen t we record every patient’s age, height,body weight, body mass index and th e time of menopause. Treatment group receives Jinkui shenqi pills, the norm al control group receives nothing while the positive control group receiv es Alendronate. During the study we use ELISA to measure serum sclerostin and DXA to measure bone mineral density. After three or six Months of trea tment with Jinkui shenqi pills or Alendronate we evaluate each groups’se rum sclerostin,bone mineral density and the score of traditional Chinese medicine syndrome types to compare the distinction of three groups.Results1. Before treatment, the serum sclerostin and bone mineral density in treatment group has no significant distinction than which in positive control group. The two groups of bone mineral density is lower than normal control group while The two groups of serum sclerostin is higher than normal control group. Score of traditional Chinese medicine syndrome types in treatment group and positive control group are higher than normal control group, but treatment group and positive control group have no obvious difference.2. After three months of treatment, the serum sclerostin of treatment group and positive control group still has no obviously distinction, both of which are still higher than normal control group but lower than which before treatment. The bone mineral density of treatment group are significantly lower than which in positive control group but higher than which before treatment. The score of treatment group are significantly lower than which in positive control group and than which before treatment but higher than which in normal control group.3. After six months of treatment, the serum sclerostin of treatment group are significantly higher than which in positive control group but lower than which before treatment. The bone mineral density of treatment group are significantly lower than which in positive control group but higher than which before treatment. The score of treatment group are significantly lower than which in positive control group and than which before treatment while the gap is becoming more apparent.ConelusionThe serum sclerostin was increased in postmenopausal osteoporosis patients than which in normal people, and was decreased after treated with Chinese herbal medicine which invigorate the kidney. Alendronate may show its superiority in improving bone mineral density, but it has no effect in relieving the symptoms of traditional Chinese medicine compared whih Jinkui shenqi pills.