The Study Of Academic Thought And Medication Rule Of Professor Yang Nizhi For Treating Chronic Renal Failure By Data Mining Method

ObjectiveThis study aims to explore the etiology, pathogenesis dialectical, and herbal prescription theory of chronic renal failure (CRF), which is Professor Yang Nizhi’s understanding. This paper summarizes the professor Yang Nizhi’s clinical experience, drug characteristics, prescription rules by supplementing qi and activating blood circulation method when treating chronic renal failure, Thus, the study provide visual experience for the clinicians. Besides, this study can make the old famous traditional Chinese medicine doctorsex’perience more widely spread and applicated.MethodsThis study collected 120 cases, a total of 480 diagnosis. The period was From January 2015 to December 2015 in Guangdong Province Hospital of traditional Chinese medicine Professor in Yang Nizhi clinic, all the patients were diagnosed with chronic renal failure treatment, which were collected strictly in accordance with integrated traditional Chinese and Western medicine diagnostic criteria of the chronic renal failure, inclusion criteria, exclusion criteria for screening. Established basic information table EXCEL for the cases which is according with the standard of medical records of patients.Collect the basic information, clinical symptoms, diagnosis,and treatment of traditional Chinese medicine and Western medicine prescription, and then All the clinical data are using TCM inheritance auxiliary platform software to establish clinical case collections and database storage. Finally, by using frequency statistics, association analysis, strengthen the drug association rules data mining operation model of mining. By analyzing and summarizing the results of data mining, the professor Yang treatment law of prescription drugs for the treatment of chronic renal failure, new prescription drugs, association rules between the new drug combination and the treatment of chronic renal failure can be obtained.ResultsBy the analysing the medical records of 120 patients with 480 cases, As can be seen in the dialectical, Professor Yang Nizhi proposed "blood stasis" mainly for chronic renal failure disease machine, And put forward the" strenthening Qi and promoting blood circulation, removing blood stasis for the treatment of chronic renal failure. which mianly contain five syndrome: Qi deficiency and blood stasis of spleen and kidney;Qi and yin deficiency, damp heat and blood stasi; Qi and yin deficiency, damp heat and blood stasis;Spleen and kidney qi deficiency, water resistance Shiyu;Spleen kidney qi deficiency, dampness and blood stasis obstruction. By summerise frequency of the symptoms of chronic renal failure (CRF),we can known that fatigue, soreness of waist, lumbago, edema is common. The using frequency of medication is greater than 250 times has licorice root, Herba Lycopi, Radix Astragali, radix salviae miltiorrhizae, Fructus Ligustri Lucidi, Radix Paeoniae Alba, sunburn, Polygonum multiflorum Thunb. At the same time confidence degree is equal to or greater than 0.98 medicine of peach kernel and Herba Lycopi, adenophorum_ Radix Rehmanniae Preparata, adenophorum Radix Astragali prepared rhizome of rehmannia, Salvia miltiorrhiza and Radix Rehmanniae Preparata, Salvia miltiorrhiza and Radix Rehmanniae Preparata, Salvia miltiorrhiza and Rhizoma Atractylodis Macrocephalae and Radix Paeoniae Alba, Radix Astragali_ Rehmannia yellow.Through the statistics and data mining of 480 prescriptions, we summed up the new 3 group is associated with a higher degree of the treatment of chronic renal failure:Prepared rehmannia root, white atractylodes rhizome, Herba Ecliptae, peach kernel, dogwood, Radix Astragali, Herba Lycopi, radix salviae miltiorrhizae, Fructus Ligustri Lucidi, Prepared Radix Polygoni Multiflori, Zeeland, pseudostellaria root, Radix Fici Hirtae, Eclipta alba, Radix et Rhizoma Rhei.ConclusionProfessor Yang Nizhi believes that pathogenesis of chronic renal insufficiency is mainly Qi deficiency and blood stasis type, the disease is mainly relation to the kidney, the latter of the disease is more involved in the lung, spleen. The main pathological factors of chronic renal failure (CRF) is due to "turbidity, blood stasis, heat damp", and treatment of the disease is mainly about tonifying kidney, invigorating spleen, tonifying Qi, activating blood and eliminating dampness. The herbs which is commonly used in chronic renal failure (CRF) conclude Salviamiltiorrhiza, Radix Codonopsis, Radix et Rhizoma Rhei, Radix Paeoniae Alba, Herba Lycopi, astragalus root, white atractylodes rhizome, glossy privet fruit, prepared rehmannia root, peach kernel, Radix Polygoni Multiflori, dodder seed, tangerine peel. The main symptoms of chronic renal failure is fatigue, backache, back pain, edema, proteinuria.Assisted by traditional Chinese Medicine Inheritance software, We can get drug combinations:Salvia miltiorrhiza, Herba Lycopi, Zeeland, Radix Paeoniae Alba, Ze, licorice root, Ligustrum lucidum. Besides, by the traditional Chinese Medicine Inheritance software, we can get new prescriptions for treating chronic renal disease:Prepared rehmannia root, white atractylodes rhizome, Herba Ecliptae, peach kernel, dogwood, Radix Astragali, Herba Lycopi, radix salviae miltiorrhizae, Fructus Ligustri Lucidi, Prepared Radix Polygoni Multiflori, Zeeland, pseudostellaria root, Radix Fici Hirtae, Eclipta alba, Radix et Rhizoma Rhei.