| Objective:To investigate the value of serum von Willebrand factor(vWF) as a marker of subclinical atherosclerosis by determining the carotid intima-media thickness(IMT) in patients with type 2 diabetes. To provide certain theoretical basis on clarifying the role of in the formation of artery plaque in T2 DM patients by analyzing the correlation of v WF and glucolipid metabolism and inflammatory factor. To explore the possibility of v WF as a new target spot for early diagnosis, intervention and treatment in T2 DM patients with macroangiopathy.Methods: Ultrasonographic measurement of bilateral carotid artery IMT was performed for 120 type 2 diabetes patients, and patients were divided into groups according to a carotid IMT !1.5 mm(n=60) and <1.0 mm(n=60). Fifty-six healthy participants were included as a control group. Patients’ demographic data and baseline characteristics were collected. Pearson correlation tests and assessment using forward stepwise multivariate regression were performed.Results: Serum v WF levels in diabetes patients with a carotid IMT <1.0 mm were significantly higher than those in healthy controls, but lower than those in diabetes patients with a carotid IMT !1.5 mm(P<0.05). The serum v WF level was positively correlated with the levels of trigelyceride(r=0.20, P=0.042), high sensitivity C-reactive protein(r=0.270, P=0.011), systolic blood pressure(r=0.210,P=0.049),fasting plasma glucose(FPG, r=0.504, P<0.001), and hemoglobin A1c(r=0.44, P<0.001) and negatively correlated with high-density lipoprotein cholesterol(HDL-C, r=-0.28, P=0.008). v WF levels 、 Hb A1 c and HDL-C were independently associated with carotid plaques in type 2 diabetes patients.Conclusion:Elevated serum levels of v WF may be related to an increased risk of developing carotid plaques in type 2 diabetes patients, and thus, the serum v WF level may represent a systemic biomarker of subclinical atherosclerosis for such a population. |
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