BSA-Mediated Synthesis Of Bismuth Sulfide Nanotheranostics For Tumor Multimodal Imaging And Thermoradiotherapy

Nanomaterials integrated with different diagnostic and therapeutic functional agents have been arguably the most active area of nanomedicine research. For applications of these nanoplatforms, X-ray responsive CT and radiosensitizing enhancement have get popularly attention. Moreover, near-infrared(NIR) light triggered photoacoustic(PA) imaging and photothermal therapy(PTT) would be minimally or non-invasive theranostic modality. We hope to find a simple way to construct a nanoparticle efficiently integrating both X-ray and NIR light responsive nanoplatforms, for combined diagnostic and therapeutic is more preferable for enhanced antitumor efficacy.In view of bismuth sulfide nanoparticles(Bi2S3 NPs) with high NIR absorption coefficient and the larger X-ray attenuation coefficient of bismuth element, we plan to employ one-pot albumin-based biomineralization approach to synthesize a one-for-all Bi2S3 NPs and test its characterization, then establish animal models of tumor for PA/CT imaging and thermo-radiotherapy applied research.The resulting Bi2S3 NPs exhibit simple structure, excellent biocompatibility, intense stability, high tumor targeting. Bi2S3 NPs with good NIR absorption property and large X-ray attenuation coefficient for multimodal imaging features including ultrasensitivity and precise anatomical localization. Meanwhile, Bi2S3 NPs exhibit NIR-responsive photothermal effect and X-ray triggered radiosensitizing enhancement results in tumor ablation upon irradiation.In summary, we fabricated a one-for-all nanoparticle through an optimized biomineralization process,and explored its applications in tumor multimodal imaging and thermo-radio therapy. The multifunctional nanoparticle would have promising potentials in the field of cancer theranostics.