| Bone defects caused by trauma, malformations and tumors are the main challenge currently facing clinical orthopedics. There are traditional means of repair autologous and allograft, their application due to different kinds of factors is limited. Therefore, the development has good mechanical properties, biocompatibility of bone repair material is hotspots and difficulties current research. Hydroxyapatite is the main component of the vertebrate skeleton inorganic, it has biocompatible and osteoinductive properties, it is widely used in clinical bone defects repair. Simplex HA bioactive ceramics exist brittle, degradation and adsorption remineralization at slow speeds and other faults. In this study, hydroxyapatite and strontium oxide as raw material, the strontium in the form of SrO incorporated HA, obtain SrO/HA composite powder. Construction porous SrO/HA biocomposites ceramic bone repair material by spark plasma sintering technology, through the study of the material porosity, microstructure and mechanical properties, degradation behavior and mineralization and preliminary in vitro biological compatibility performance, The results showed that addition of SrO effectively improve the mechanical properties of materials, the compressive strength above 335MPa were prepared to improve the degradation of HA ceramics containing strontium content of porous SrO 3～7% between/HA biological ceramic composite bone repair material has the best performance degradation and mineralization of deposits. Non-toxic materials and blood, no significant cytotoxicity, cell proliferation and added SrO has a certain role in promoting comparative analysis of the amount of strontium-containing cell activity best composite ceramic material is between 3-7%.In summary, the optimal performance of the strontium content in the range of the prepared material is between 3-7%. This study is a porous SrO/HA bio-composite ceramic materials for bone repair in bone defect repair has laid a theoretical and experimental basis. |
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