Effect Of Oligosaccharide Supplement On Reproductive Hormones And Energy Metabolism In Athletes With Exercise-Associated Menstrual Disturbance

Objective This study is based on the theory that the energy balance is the key factor to cause the menstrual cycle disorder.To verify whether carbohydrate beverage supplement can correct athletic menstrual disorders, this research explores the effects of Carbohydrate beverage supplement intervention of female athletes,increases the energy intake,on HPO axis hormone substrates and energy metabolic hormones, maintaining the athletes under the condition of normal diet and training.To provide reference for the prevention and treatment of Exercise-Associated Menstrual Disturbances.Methods Participants of the study are 14 athletes with Exercise-Associated Menstrual Disturbances 8 of long-distance race team and 6 of Sanda team of the athletics sports school affiliated to Shanghai University of Sport.Carbohydrate beverage supplement intervention project:Through health education at the same time delivered menstrual cycle disorder questionnaire, tracking athletes from menstrual of the twelfth day of the morning urine LH changes and blood related HPO axis hormone detection.In the early days of the follicle, continual 5 days of dietary energy intake and energy consumption were monitored to assess the energy balance of the athletes, in that calculate the daily Carbohydrate beverage supplement. Taking Exercise-Associated Menstrual Disturbances and energy balance as the inclusion criteria. Randomly divided into the intervention group and the control group, the 7(two sports items in the same proportion), to carry on the research of the intervention of the Carbohydrate beverage supplement.The supplement of the oligosaccharide solid beverage was 3 menstrual cycles during the training period from Monday to Sunday. In the preintervention and postintervention, measured height, body weight, body fat content of participants,at the same time,respectively,in the intervention of previous menstrual cycle and the process of intervention of the third menstrual cycle of the 14±2 days(late follicular phase) and the 22±2 days(midluteal) were testing blood samples(a total of 4 times of blood)including Gn RH, FSH, LH, E2 and P hormone of serum.Results1. 14 participants were all Exercise-Associated Menstrual Disturbances.The questionnaire showed 1 athletes for amenorrhea; morning urinary LH values and blood sex hormone detection results showed that 4 athletes luteal function incomplete(a short luteal phase), 8 athletes no LH peak and one player progesterone is too low.2. Through intervention, whether comparison among groups or within group comparison there were no significant differences in the levels of BMI,body weight,height and body fat between the two groups.3. 14 participants daily endrgy intake can not meet the needs of daily energy consumption.They were in a state of negative balance. In the preintervention tow groups energy were negative banance(intervention group =-468.9kcal vs control group =-445.6kcal). In the postintervention tow groups energy were changed respectively(intervention group =132.5kcal vs control group=-188.5kcal).Independent samples t-test showed that both groups were no statistical difference in energy balance in the preintervention,however,both groups had statistical difference in energy balance in the postintervention(p=0.03).Matched sample t-test showed that the control group had no significant difference, the intervention group had significant difference(p=0.019).4. Through intervention, whether comparison among groups or within group comparison there were no significant differences in the levels of Gn RH, FSH and LH between the two groups in the folliclllar phase and the luteal phase.5. Compared with the control group, the intervention group were significant differences in P in the folliclllar phase and E2 in the luteal phase levels after the intervention(p=0.026 vs p=0.018)between the groups. E2 in the intervention group increased from 52.4pg/ml to 88.5pg/ml in the follicular phase,and E2 in the control group was reduced from 42.17pg/ml to 36.71pg/ml in the follicular phase.The P in the intervention group increased from 6.75ng/ml to 7.70ng/ml in the luteal phase, and the control group increased from 1.97ng/ml to 2.02ng/ml luteal phase.There was no significant difference within group comparison.Conclusion1. Three continual menstrual cycle of carbohydrate drinks supplement did not affect the athletes’ BMI, body weight, body height and body fat, and did not increase the burden on the fitness of athletes.2. Thought three continual menstrual cycle of carbohydrate drinks supplement,athletes from the negative balance of energy to the positive balance of energy.The results showed that the supplementation of carbohydrate beverage could increase the energy intake and restore the energy metabolism of the athletes.3. The reproductive hormone level of the Exercise-Associated Menstrual Disturbances athletes can be recovered to some extent by the supplementation of the oligosaccharides, and the improvement of the serum P in the luteal phase and the E2 in the follicular phase level has statistical significance.It was confirmed that the carbohydrate supplement was beneficial to the recovery the Exercise-Associated Menstrual Disturbances.