A Clinical Ctudy For The Treatment Of Patients With Ovary Dysfunction, Spleen And Kidney Deficiency With Zishen Yutai Pill Combined With Acupuncture

ObjectiveThis study, adopting acupuncture combined with Zishen Yutai pill treatment, studies whether Zishen fertility embryo pill can improve ovarian function decline of ovarian function in women.MethodThis study adopts comparative experiments, collecting 40 cases, which are divided into the treatment group and the control group, included in the standard from March 2015 to March 2016 in gynecological clinic of the First Affiliated Hospital of Guangzhou University of traditional Chinese medicine. The treatment group was treated with acupuncture which combined with Zishen Yutai pill, and the patients in the control group were treated with acupunct-ure which combined with vitamin E soft capsule group. The treatment time was last for 3 months. Before and after treatment, the writer observes changes of menstruation, clinical symptoms, TCM syndrome score, measuring basal follicle-stimulating hormone (FSH) luteinizing hormone(LH), estradiol (E2), inhibin B (INH-B), anti-mullerian hormone(AMH) in the 2 or 3 day of the menstrual cycle, after the period index changes of ovarian volume(MOV), antral follicle count (AFC), ovarian stromal artery peak flow velocity (PSV), resistance index (RI) etc. will be observed through transvaginal color ultras-ound observation. The collected data will be analysed by SPSS22.0 software package, there exist difference if P value less than or equal to 0.05.Results1. Comparability of casesBefore the treatment, the comparison btween treatment group and control group in age, height, weight, duration of illness, pregnancy flow, the syndrome score, serum FSH, LH, FSH/LH, E2, AMH and Inhibin-B, endometrial, bilateral ovarian volume, antral follicle number (AFC), ovarian artery peak systolic velocity (PSV), and ovarian resistance index (RI) shows that difference is not statistically significant (P>0.05). There exists a difference between the left MOV groups, because of the unequal of baseline, the covariation analysis method is adopted.2. Comparison of curative effect of TCM syndrome between two groupsAfter the treatment, the total score of the main syndrome and the total score of the syndrome of the treatment group are decreased compared with that before treatment, the difference is statistically significant (P<0.05). In the control group, the total score of the main syndrome and the total score of the syndrome are also decreased compared with before treatment, the difference is statistically significant (P<0.05). However, the comparison between the two groups shows that the treatment group in all symptoms is higher than the control group, so the difference is statistically significant (P <0.05).3. Comparison of two groups of endocrine hormones and cytokines in Western MedicineThere is a significant difference in the treatment group(P<0.05), the serum FSH and LH decreases. The serum E2 decreases while FSH/LH and INH-B increases, so the difference was not significant (P>0.05). In the control group, the serum FSH and INH-B increases, and LH and serum E2 decreases, the difference is not significant (P>0.05). FSH/LH and INH-B decreases, and the difference is significant (P<0.05). When compared the mean of serum FSH, LH and AMH in two groups, the statistic shows that there is a significant difference (P<0.05).4. Comparison of two groups of B ultrasound parametersThe endometrial thickness of the treatment group, increases as well as the left MOV and PSV, and the left RI decreases, the deference has statistical significant (P<0.05), while bilateral AFC, left MOV and PSV, and left RI decrease, the deference doesn’t have statistical significant (P>0.05). However, the left MOV of control group decreases, the difference was statistically significant (P<0.05). The right AFC, left PSV and bilateral RI increase, with the endometrial thickness, bilateral MOV, right PSV decreasing, the left AFC shows no difference, so the difference was not statistically significant (P>0.05). On a whole, comparing the mean of endometrial thickness, left MOV, left PSV, and left RI, there exists a significant (P<0.05).5. Comparison between the two groupsIn the kidney nourishing pill group,3 cases were cured,6 cases were markedly effective,8 cases were effective,1 cases were ineffective and the total effective rate was 94%. In the control group,1 cases were cured, 1 cases were markedly effective,9 cases were effective, the total effective rate was 58%. The statistics processing P<0.01, the difference between Chinese medicine and Western medicine groups is not statistically significant.Conclusion1. Zishen Yutai pill combined with acupuncture can effectively improve the declining of ovarian function in patients with menstrual disorders, including regulating alleviate hot flushes, sweating, irritability, vaginal dryness, soreness and weakness of waist and knees, fatigue and other symptoms. The treatment group is better than the control group.2. Zishen Yutai pill combined with acupuncture can improves the ovary function and increases the rate of preglance through lowering the figures of serum FSH and LH, and enhancing AMH.3. Zishen Yutai pill combined with acupuncture thickens endometrium of DOR patients, improves MOV and PSV, and lowers RI, thus improving the ovary function.4. Zishen Yutai pill is a kind of drug which is worth promoting the use of the treatment of ovarian dysfunction.