Association Between Urinary Albumin To Creatinine Ratio,eGFR And UKPDS Cardiovascular Risk In Type 2 Diabetes Mellitus

Objective:Both estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) are markers of renal dysfunction and have been reported to be independent risk factors for cardiovascular disease (CVD), but there are few studies that have assessed these two parameters and their association with CVD at the same time in diabetic patients. The purpose of the present study was to assess the association between chronic kidney disease (CKD) and coronary heart disease (CHD), stroke risk in a Chinese population with type 2 diabetes mellitus (T2DM).Methods:A total of 1401 patients were included in this study and of whom both UACR and eGFR were tested. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for Asians (CKD-EPI-ASIA) was used to measure eGFR. The UK Prospective Diabetes Study (UKPDS) Risk Engine was used to estimate CHD and stroke risk.Results:A significant inverse association between CKD stages and CVD risk was found. The patients at higher CKD stages had higher CHD risk, fatal CHD risk, stroke risk, fatal stroke risk compare to those who were at lower CKD stages or had no CKD. In groups with higher CKD level, the percentage of individuals with high risk of CHD and stroke was observed increase. Similar results was found in groups with severe urine albumin excretion.Conclusions:In patients with type 2 diabetes in Zhejiang, China, both increased UACR and CKD level were associated with the increase of CHD and stroke risk.