The Analysis Of Treatment And Follow-up Of 13 Patients With Long QT Syndrone

Background:Long QT syndrome(LQTS) refers to a disease that shows a prolongation of the QT-interval for various reasons-Severe Ventricular arrhythmias or even 1 sudden cardiac death can occur in patients with LQTS.Therefore,China issued Expert Consensus Statement on the Diagnosis and Management of Patients with Inherited Primary Arrhythmia Syndromes in 2015,including LQTS in order to standardize the diagnosis and treatment of LQTS.This research retrospectively analyzed the process of diagnosis and treatment in LQTS patients admitted in our hospital.Methods:This research selects 13 patients who were hospitalized in cardiology department and whose discharge diagnosis are "Long QT syndrome"from 2010.1.1 to 2015.12.31.Within whom there are 12 (92.3%)males and 1 (7.7%) females with an average age of 61.46±19.50 years old.The research analyzes the process of treatment and conducted a follow-up.Results:Within the 13 patients,patient(7.7%)has a family history of LQTS,3 patients (23.1%)has a history of using QT-interval prolonging drugs,2 patients(15.4%) has a history of using β-blockers.The average corrected-QT interval of the patients is 490.2±38.5ms when they are admitted to hospital,5 patients(38.5%) has T-Wave change,9 patients has a history of Tosade de points(TdP).According to the guideline,8(61.5%) patients were diagnosed as inherited LQTS,5 (38.5%)patients were diagnosed as secondary LQTS.Within the 8 patients diagnosed as inherited LQTS,5 patients were given metoprolol as drug therapy,1 patient(12.5%) wasn’t given β-blockers because she has P-blocker contraindications,2 patients(25%) were not given β-blockers for unknown reasons,7 patients(87.5%) had implanted implantable cardio-verter defibrillators(ICD),l patients(12.5%) refused ICD therapy.Within the 5 patients diagnosed as secondary LQTS,1 patient(25%) had implanted a DDD pacemaker,3 patients(75%) had ICDs implanted because of the existence of high-risk factors.After a mean of 34.8±22.4 months of follow-up,within the 7 inherited LQTS patients who were implanted ICD,4 patients(57.1%) was recorded appropriate discharge,while within the 4 secondary LQTS patients who were implanted ICD,3 patients(75%) was recorded appropriate discharge.Conclusion:The use of P-blockers can reduce the occurrence of syncope symptoms,but there is still room for improvement of the usage rate and usage and dosage of β-blockers. ICD can reduce the risk of sudden cardiac death inpatients for various reasons.